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首页> 外文期刊>Materials Chemistry and Physics >Synthesis and characterization of semi-interpenetrating polymer network hydrogel based on chitosan and poly(methacryloylglycylglycine)
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Synthesis and characterization of semi-interpenetrating polymer network hydrogel based on chitosan and poly(methacryloylglycylglycine)

机译：基于壳聚糖和聚（甲基丙烯酰基甘氨酰甘氨酸）的半互穿聚合物网络水凝胶的合成与表征

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摘要

Objective of the present work was the development of a strategy for the synthesis of semi-interpenetrating networks (semi-IPN) based on chitosan and poly(methacrylamide) under physiological conditions. Free radical polymerization of methacryloylglycylglycine (MAGG) in the presence of chitosan and ethylene glycol dimethacrylate as the crosslinker was performed. Chitosan and poly(MAGG) hydrogels having different composition and amount of crosslinker were prepared. The presence of the two polymeric components in the polymer bulk was confirmed by fourier transform infrared spec-troscopy (FTIR); thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were used to further substantiate the structural feature of the semi-IPN hydrogels. Finally, degradation behavior promoted by lysozyme demonstrated that there was 60%, 68% and 76% of degradation of the semi-IPN hydrogel with 8%, 4% and 2% of crosslinker respectively in 28 days. The preliminary investigations of the prepared materials suggest their suitability for applications in tissue engineering and controlled release of bioactive agents.
机译：本工作的目的是在生理条件下开发基于壳聚糖和聚（甲基丙烯酰胺）的半互穿网络（semi-IPN）合成策略。在壳聚糖和乙二醇二甲基丙烯酸酯作为交联剂的情况下，进行了甲基丙烯酰基甘氨酰甘氨酸（MAGG）的自由基聚合。制备了具有不同组成和数量的交联剂的壳聚糖和聚（MAGG）水凝胶。通过傅里叶变换红外光谱法（FTIR）证实了聚合物本体中两种聚合物组分的存在；使用热重分析（TGA）和差示扫描量热法（DSC）进一步证实了半IPN水凝胶的结构特征。最后，溶菌酶促进的降解行为表明，在28天之内，半IPN水凝胶的降解率分别为60％，68％和76％，其中交联剂分别为8％，4％和2％。对所制备材料的初步研究表明它们适用于组织工程和生物活性剂的控制释放。

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  • 来源
    《Materials Chemistry and Physics》 |2012年第3期|1070-1076|共7页
  • 作者

    Mamoni Dash; Marcella Ferri; Federica Chiellini;

  • 作者单位

    Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy;

    Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy;

    Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications (BIOlab), UdR INSTM, Department of Chemistry and Industrial Chemistry, University of Pisa, Pisa, Italy;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    chitosan; differential scanning calorimetry (DSC); fourier transform infrared spectroscopy(FTIR); thermal properties; hydrogels;

    机译：壳聚糖差示扫描量热法（DSC）;傅立叶变换红外光谱（FTIR）;热性能;水凝胶;

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