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首页> 外文期刊>Materials Chemistry and Physics >Interactions Between O-carboxymethylchitosan And Bovine Serum Albumin
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Interactions Between O-carboxymethylchitosan And Bovine Serum Albumin

机译：O-羧甲基壳聚糖与牛血清白蛋白的相互作用

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摘要

Interactions between proteins and biocompatible polysaccharide have been investigated owing to their scientific and technological importance. In this study, the interactions between O-carboxymethylchitosan (OCMCS) and bovine serum albumin (BSA) are characterized by circular dichroism (CD); isothermal titration calorimetric (ITC); ultraviolet (UV) spectrum; fluorescence spectrum and transmission electron microscopy (TEM) techniques. The CD and fluorescence spectrum indicate that the conformation of BSA does not change significantly within 0.25 mg ml~(-1) of OCMCS, however, higher concentration of OCMCS makes BSA denaturation. The formed composite of OCMCS and BSA shows nanospheric morphology revealed by TEM technique. The complex formation is driven by the H-bond and hydrophobic interactions. This study demonstrates that OCMCS has great potential as a matrix for delivery of the drugs such as proteins and polypeptides.
机译：由于其科学和技术重要性，已经研究了蛋白质与生物相容性多糖之间的相互作用。在这项研究中，O-羧甲基壳聚糖（OCMCS）与牛血清白蛋白（BSA）之间的相互作用以圆二色性（CD）为特征。等温滴定热法（ITC）;紫外线（UV）光谱;荧光光谱和透射电子显微镜（TEM）技术。 CD和荧光光谱表明，在0.25mg ml-1（-1）的OCMCS中BSA的构象没有明显变化，但是，较高浓度的OCMCS会使BSA变性。形成的OCMCS和BSA的复合物通过TEM技术显示出纳米球形态。络合物的形成是由氢键和疏水相互作用驱动的。这项研究表明，OCMCS作为传递蛋白质和多肽等药物的基质具有巨大潜力。

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