Indocyanine green (ICG) - Menthol loaded cerasomal nanoparticles for ultrasound imaging and photothermal therapy against tumor

Yang Xi; Wang Chunan; Ding Mengli; Zhang Chunyang; Wang Wei; Cao Zhong

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Indocyanine green (ICG) - Menthol loaded cerasomal nanoparticles for ultrasound imaging and photothermal therapy against tumor

机译：吲哚菁绿（ICG）-薄荷醇负载的陶瓷体纳米颗粒，用于超声成像和光热疗法治疗肿瘤

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Multifunctional ultrasound contrast agents (UCAs) combining ultrasonic diagnosis with tumor therapy have received enormous attentions in virtue of their good biocompatibility and high biological penetration ability. However, nanoscale UCAs with suitable size and good therapeutic effect remain to be developed in future studies. Herein, indocyanine green and L-menthol loaded hybrid cerasomes (ICG-MCNs) was fabricated as a multifunctional theranostic nanoplatform, which exhibited high structure stability and photo-stability in aqueous. Mutual assistance with the photothermal effect of ICG, heating triggered tri-phase transition of L-menthol could produce continuous gas microbubbles for enhanced ultrasound imaging. Thus, the resultant ICG-MCNs is anticipated to be a competent candidate for US imaging and photothermal therapy. (C) 2019 Elsevier B.V. All rights reserved.

机译：超声诊断与肿瘤治疗相结合的多功能超声造影剂（UCA），以其良好的生物相容性和较高的生物渗透能力而受到广泛关注。然而，在未来的研究中，具有合适尺寸和良好治疗效果的纳米级UCA尚待开发。在这里，吲哚菁绿和负载L-薄荷醇的混合体（ICG-MCNs）被制造为多功能的theranostic纳米平台，表现出高的结构稳定性和在水中的光稳定性。在ICG的光热效应的相互协助下，加热触发的L-薄荷醇的三相转变可以产生连续的气体微气泡，以增强超声成像效果。因此，预期所得的ICG-MCNs将是美国成像和光热疗法的合格候选者。（C）2019 Elsevier B.V.保留所有权利。

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来源
《Materials Letters》 |2019年第15期|126524.1-126524.4|共4页
作者
Yang Xi; Wang Chunan; Ding Mengli; Zhang Chunyang; Wang Wei; Cao Zhong;
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作者单位

Sun Yat Sen Univ Sch Biomed Engn Guangzhou 510006 Guangdong Peoples R China;

Sun Yat Sen Univ Affiliated Hosp 1 Inst Diagnost & Intervent Ultrasound Dept Med Ultrasound Guangzhou 510080 Guangdong Peoples R China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
原文格式 PDF
正文语种 eng
中图分类
关键词
Cerasome; Ultrasound imaging; Photothermal therapy; Biomaterials; Nanoparticles;

机译：陶瓷体超声成像;光热疗法;生物材料;纳米粒子;

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2. Folate-Targeted and Oxygen/Indocyanine Green Loaded Lipid Nanoparticles for Dual-Mode Imaging and Photo-Sonodynamic/Photothermal Therapy of Ovarian Cancer in Vitro and in Vivo (vol 16, pg 4104, 2019) [J] . Liu Yujiao, Chen Shuning, Sun Jiangchuan, Molecular pharmaceutics . 2020,第4期

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6. Folate-receptor-targeted laser-activable poly(lactide-co-glycolic acid) nanoparticles loaded with paclitaxel/indocyanine green for photoacoustic/ultrasound imaging and chemo/photothermal therapy [O] . Fengqiu Liu, Yuli Chen, Yizhen Li, 2018

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5. Indocyanine green (ICG) compositions and related methods of use [P] . 外国专利： US6944493B2 . 2005-09-13

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Indocyanine green (ICG) - Menthol loaded cerasomal nanoparticles for ultrasound imaging and photothermal therapy against tumor

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