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首页> 外文期刊>Materials Research Innovations >Degradation behaviour and biological properties of gelatin/hyaluronic acid composite scaffolds
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Degradation behaviour and biological properties of gelatin/hyaluronic acid composite scaffolds

机译：明胶/透明质酸复合支架的降解行为及其生物学特性

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Hydrogels, based on natural polymers, are gaining attention as possible cell scaffolding materialsnfor the regeneration of a variety of tissues. In this work, gelatin (Gel) and hyaluronic acid (HA) werenused to fabricate novel scaffold materials using 1-ethyl-3-(3-dimethylaminopropyl) carbodiimidenas a cross-linker. The degradation behaviours of Gel/HA scaffolds in phosphate buffered salinen(PBS) and PBS solution containing lysozyme were investigated respectively. The biologicalnproperties including haemolytic activity and acute systemic toxicity were also studied. The resultsnshowed that the scaffold had an interconnected pore structure with an average pore size of aboutn100–500 mm. The degradation of Gel/HA scaffolds in PBS solution containing lysozyme was fasternthan that in PBS solution. The haemolytic ratio of 0?340–0?781% indicated that the Gel/HAnscaffolds have a good blood compatibility. The acute systemic toxicity test showed that Gel/HAnextracts have no acute systemic toxicity.
机译：基于天然聚合物的水凝胶作为可能的细胞支架材料正在引起人们的关注，用于多种组织的再生。在这项工作中，使用1-乙基-3-（3-二甲基氨基丙基）碳二亚胺交联剂，对明胶（Gel）和透明质酸（HA）进行制造新型支架材料。分别研究了Gel / HA支架在磷酸盐缓冲液（PBS）和含溶菌酶的PBS溶液中的降解行为。还研究了包括溶血活性和急性全身毒性在内的生物学特性。结果表明，支架具有相互连接的孔结构，平均孔径约为100-500 mm。在含有溶菌酶的PBS溶液中，Gel / HA支架的降解要比在PBS溶液中的降解更快。溶血率为0？340–0？781％，表明Gel / HAnscaffolds具有良好的血液相容性。急性全身毒性试验表明，Gel / HAnextracts没有急性全身毒性。

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