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首页> 外文期刊>Materials Science and Engineering >Some applications of nanotechnologies in stem cells research
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Some applications of nanotechnologies in stem cells research

机译：纳米技术在干细胞研究中的一些应用

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摘要

Stem cell based tissue engineering therapies involve the administration of ex vivo manipulated stem cell populations with the purpose of repairing and regenerating damaged or diseased tissue. Currently available methods of monitoring transplanted cells are quite limited. To monitor the outcomes of stem cell therapy longitudinally requires the development of non-destructive strategies that are capable of identifying the location, magnitude, and duration of cellular survival and fate. The recent development of imaging techniques offers great potential to address these critical issues by non-invasively tracking the fate of the transplanted cells. This review offers a focused presentation of some examples of the use of imaging techniques connected to the nanotechnological world in research areas related to stem cells. In particular investigations will be considered concerning tissue-engineered bone, treatment of intervertebral disc degeneration, treatment by human stem cells of muscular dystrophy of Duchenne in small animal models and the repair of spinal cord injuries.
机译：基于干细胞的组织工程疗法涉及给予离体操作的干细胞群体，以修复和再生受损或患病的组织。目前可用的监测移植细胞的方法非常有限。为了纵向监测干细胞治疗的结果，需要开发能够确定细胞存活和命运的位置，大小和持续时间的非破坏性策略。成像技术的最新发展为通过非侵入性跟踪移植细胞的命运解决这些关键问题提供了巨大潜力。这篇综述重点介绍了在与干细胞有关的研究领域中，与纳米技术世界相关的成像技术的一些使用实例。特别是在小动物模型中，将考虑进行以下研究：组织工程化骨，椎间盘退变的治疗，杜兴氏肌营养不良的人类干细胞治疗以及脊髓损伤的修复。

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  • 来源
    《Materials Science and Engineering》 |2009年第3期|139-147|共9页
  • 作者

    M. Belicchi; R. Cancedda; A. Cedola; F. Fiori; M. Gavina; A. Giuliani; V.S. Komlev; S. Lagomarsino; M. Mastrogiacomo; C. Renghini; F. Rustichelli; E. Sykova; Y. Torrente;

  • 作者单位

    Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122, Italy;

    Istituto Nazionale per la Ricerca sul Cancro and Dipartimento di Oncologia Biologia e Genetica - Universita di Genova, Largo R. Benzi 10, Genova 16132, Italy;

    Istituto di Fotonica e Nanotecnologie - CNR, Via Onto Romano 42, Roma 00156, Italy;

    Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Blanche, Ancona 60131, Itaty INBB - Istituto Nazionale Biostrutture e Biosistemi, Italy CNISM - Matec (Ancona), Italy;

    Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122, Italy;

    Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Blanche, Ancona 60131, Itaty CNISM - Matec (Ancona), Italy;

    Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Blanche, Ancona 60131, Itaty Institute for Physical Chemistry of Ceramics, Russian Academy of Sciences, Ozernaya 48, 119361 Moscow, Russia;

    Istituto di Fotonica e Nanotecnologie - CNR, Via Onto Romano 42, Roma 00156, Italy;

    Istituto Nazionale per la Ricerca sul Cancro and Dipartimento di Oncologia Biologia e Genetica - Universita di Genova, Largo R. Benzi 10, Genova 16132, Italy;

    Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Blanche, Ancona 60131, Itaty INBB - Istituto Nazionale Biostrutture e Biosistemi, Italy CNISM - Matec (Ancona), Italy;

    Dipartimento S.A.I.F.E.T. Sezione di Scienze Fisiche - Universita' Politecnica delle Marche, Via Brecce Blanche, Ancona 60131, Itaty INBB - Istituto Nazionale Biostrutture e Biosistemi, Italy CNISM - Matec (Ancona), Italy;

    Department of Neuroscience, Institute of Experimental Medicine ASCR, Prague, Czech Republic;

    Fondazione IRCCS Ospedale Policlinico di Milano, Via Francesco Sforza, Milano 20122, Italy;

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  • 正文语种 eng
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  • 关键词

    imaging techniques; stem cells; nanoparticles; tissue engineering;

    机译：成像技术;干细胞;纳米粒子组织工程;

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