• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials Science and Engineering >Trypsin templated biomimetic large mesoporous silica performs favorable advantages in delivering poorly water-soluble drug
【24h】

Trypsin templated biomimetic large mesoporous silica performs favorable advantages in delivering poorly water-soluble drug

机译：胰蛋白酶模板仿生大型介孔二氧化硅在提供差的水溶性药物方面表现出有利的优势

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Mesoporous silica synthesized using biomimetic method is superior for its mild synthesis process and source saving advantages. Herein, trypsin was used as template to synthesize biomimetic mesoporous silica, and we named it biomimetic large mesoporous silica (BL-MS) due to its large mesopores. For comparison, commonly used mesoporous silica nanoparticles (MSNs) were studied along with BL-MS. The study focused on their different characteristics and abilities in delivering poorly water-soluble drug indomethacin (IMC). It turned out that BL-MS were nanoparticles with large mesopores while MSNs were nanospheres with small mesopores. As for their application, BL-MS had stronger energy to adsorb drug molecules, which can be one of its advantages as drug carrier. BL-MS and MSNs improved IMC dissolution for almost 3.5 times and 2.7 times respectively. Furthermore, BL-MS performed superior oral bioavailability and anti-inflammatory effect, which confirmed the outstanding advantages of BL-MS in delivering poorly water-soluble drugs due to its large mesopores.
机译：使用仿生方法合成的中孔二氧化硅对于其温和的合成过程和节省源优势优异。在此，胰蛋白酶用作模板以合成仿生介孔二氧化硅，并且由于其大的中孔，我们将其命名为仿生仿生大型介孔二氧化硅（BL-MS）。为了比较，研究了常用的介孔二氧化硅纳米粒子（MSN）以及BL-MS。该研究侧重于其不同的特征和能力在递送差的水溶性药物吲哚美辛（IMC）中。结果表明，Bl-MS是具有大型中孔的纳米颗粒，而MSN是具有小型中孔的纳米球。至于它们的应用，BL-MS对吸附药物的能量较强，这可以是其作为药物载体的优点之一。 BL-MS和MSNS分别改善了IMC溶解近3.5倍和2.7次。此外，BL-MS进行了卓越的口服生物利用度和抗炎作用，这证实了BL-MS由于其大型中孔而在递送差的水溶性药物中的出色优势。

著录项

  • 来源
    《Materials Science and Engineering》 |2021年第9期|115252.1-115252.8|共8页
  • 作者

    Xianbao Shi; Ping Zhang; Lingqiong Wu; Xiangyu Zhao; Jinzhu Jiang; Jing Li; Bo Yang;

  • 作者单位

    Department of Pharmacy The First Affiliated Hospital of Jinzhou Medical University 5 Renmin Street Guta Jinzhou Liaoning 121001 PR China;

    School of Pharmacy Shenyang Medical College No. 146 Huanghe North Street Shenyang Liaoning Province PR China;

    School of Pharmacy Shenyang Medical College No. 146 Huanghe North Street Shenyang Liaoning Province PR China;

    School of Pharmacy Shenyang Medical College No. 146 Huanghe North Street Shenyang Liaoning Province PR China;

    School of Pharmacy Shenyang Medical College No. 146 Huanghe North Street Shenyang Liaoning Province PR China;

    School of Pharmacy Shenyang Medical College No. 146 Huanghe North Street Shenyang Liaoning Province PR China;

    Department of Neurology The First Affiliated Hospital of Jinzhou Medical University 5 Renmin Street Guta Jinzhou Liaoning 121001 PR China;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Biomimetic large mesoporous silica; Drug dissolution;

    机译：仿生大型介孔二氧化硅;药物溶解;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号