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首页> 外文期刊>Materials Science and Engineering >Designing functional materials: DNA/Poly(3,4-ethylenedioxythiophene) interfaces for advanced DNA direct electrochemistry and DNA-Drug interaction detection
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Designing functional materials: DNA/Poly(3,4-ethylenedioxythiophene) interfaces for advanced DNA direct electrochemistry and DNA-Drug interaction detection

机译：设计功能材料：DNA /聚（3,4-亚乙二醇噻吩）界面进行高级DNA直接电化学和DNA-药物相互作用检测

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摘要

In the present study, preparation of poly(3,4-ethylenedioxythiophene) coated pencil graphite electrode with the addition of multi-walled carbon nanotubes (MWCNTs) (PEDOT nanoelectrode, NE); incorporation of double-stranded deoxyribonucleic acid (dsDNA) onto NE (dsDNA/PEDOT NE); and the bio-application of dsDNA/ PEDOT NE were described. PEDOT NEs were first used to immobilize dsDNA onto the electrode surfaces in a high efficiency to detect dsDNA with advanced oxidation signals. Afterwards, these functional biointerfaces were used for the investigation of DNA interaction with Mitomycin C (MC) and Paclitaxel (PTX) based on guanine and adenine oxidation signals. dsDNA/PEDOT NE was presented a linearity in the concentration of 1 mg L~(-1) to 50 mg L~(-1) for MC with a detection limit of 0.26 mg L~(-1). The linear range was between 0.5 mg L~(-1) and 60 mg L~(-1) for PTX with a detection limit of 0.14 mg L~(-1) (n = 3). In addition, dsDNA/PEDOT NE was presented good stability.
机译：在本研究中，通过添加多壁碳纳米管（MWCNT）（PEDOT纳米电极，NE），制备聚（3,4-亚乙二氧基噻吩）涂层铅笔石墨电极; 将双链脱氧核糖核酸（DSDNA）掺入NE（DSDNA / PEDOT NE）; 并描述了DSDNA / PEDOT NE的生物应用。 首先使用PEDOT NE以高效率将DSDNA固定到电极表面上以检测具有先进氧化信号的DSDNA。 之后，这些功能性生物界面用于基于鸟嘌呤和腺嘌呤氧化信号对丝裂霉素C（MC）和紫杉醇（PTX）进行DNA相互作用的研究。 对于MC的MC，DSDNA / PEDOT NE呈现在1mg L〜（-1）至50mg L〜（-1）的浓度的线性，检测限为0.26mg L〜（-1）。 对于PTX的PTX，线性范围为0.5mg L〜（-1）和60mg L〜（-1），其检测限为0.14mg l〜（-1）（n = 3）。 此外，DSDNA / PEDOT NE呈现出良好的稳定性。

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