• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials science & engineering >Preparation of hydroxyapatite porous scaffold from a 'coral-like' synthetic inorganic precursor for use as a bone substitute and a drug delivery vehicle
【24h】

Preparation of hydroxyapatite porous scaffold from a 'coral-like' synthetic inorganic precursor for use as a bone substitute and a drug delivery vehicle

机译：由“珊瑚样”合成无机前驱体制备羟基磷灰石多孔支架，用作骨替代物和药物递送载体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A novel surfactant free hydrothermal method was developed for the preparation of large hydroxyapatite scaffolds. Synthetic calcium carbonate (calcite) was used as the starting material which when mixed with an inorganic setting solution containing phosphoric acid and sodium hydroxide forms the porous precursor body with pore size 20–700 μm. The porous precursor body was then hydrothermally converted to hydroxyapatite scaffolds when treated in basic phosphate solution of pH 10.5 at 150 °C and 15 bar pressure maintaining the structural stability and integrity. X-ray diffraction and the Fourier transform infrared spectroscopy confirmed that the developed material consist of single phase crystalline hydroxyapatite. Surface morphology and microstructures were studied using scanning electron microscopy and porosity was evaluated by micro CT analysis. The cell material interactions evaluated by cell viability assays and live cell staining methods confirmed the cell compatibility. The drug release study at physiological pH implied that the developed materials could be promising in sustained long-term release. The results emerged have shown that the hydrothermal conversion of inorganic coral-like precursor is effective to produce porous bioactive hydroxyapatite scaffolds for bone regeneration as well as drug delivery vehicles for the treatment of infectious bone diseases such as osteomyelitis.
机译：开发了一种新型的无表面活性剂水热法，用于制备大型羟基磷灰石支架。合成碳酸钙（方解石）用作起始原料，当与包含磷酸和氢氧化钠的无机固化溶液混合后，可形成孔径为20-700μm的多孔前体。然后在150 C和15 bar压力下于pH 10.5的碱性磷酸盐溶液中处理时，将多孔前体体水热转化为羟基磷灰石支架，以保持结构稳定性和完整性。 X射线衍射和傅立叶变换红外光谱证实，所开发的材料由单相结晶羟基磷灰石组成。使用扫描电子显微镜研究表面形态和微观结构，并通过显微CT分析评估孔隙率。通过细胞活力测定和活细胞染色方法评估的细胞材料相互作用证实了细胞相容性。在生理pH下的药物释放研究表明，开发的材料在持续长期释放方面可能很有希望。结果表明，无机珊瑚状前体的水热转化可有效制备用于骨再生的多孔生物活性羟基磷灰石支架以及用于治疗诸如骨髓炎的传染性骨疾病的药物递送载体。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号