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首页> 外文期刊>Materials science & engineering >Optimization of ionic liquid-incorporated PLGA nanoparticles for treatment of biofilm infections
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Optimization of ionic liquid-incorporated PLGA nanoparticles for treatment of biofilm infections

机译：离子液体结合的PLGA纳米粒子用于生物膜感染治疗的优化

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摘要

Ionic liquids (Ms) containing imidazolium cations have a number of useful properties, such as high permeability to cells, high antimicrobial activity, and good biocompatibility. With the aid of ILs, transdermal delivery, solubilization of poorly soluble drugs were developed and therapeutic effects were improved. In this work, 1-butyl.3-methylimidazolium hexafluorophosphate-incorporated, chitosan-modified, submicron-sized poly (DL-lactide-co-glycolide) (PLGA) nanoparticles (NPs) were prepared using the emulsion solvent diffusion method for the treatment of biofilm infections. Prepared IL-incorporated PLGA NPs using surfactants such as Tween-80 and poloxamer-188 showed a high antibacterial activity to the bacterial cells under the biofilm. Additionally, antibacterial mechanism of IL-incorporated PLGA NPs was revealed by annular dark field scanning transmission electron microscopy combined a simple sample pretreatment method. We established a drug delivery system using IL-incorporated PLGA NPs to enhance the potential of polymeric nanocarriers for treating biofilm infections.
机译：含有咪唑阳离子的离子液体（Ms）具有许多有用的特性，例如对细胞的高渗透性，高抗菌活性和良好的生物相容性。借助ILs，透皮递送，难溶性药物的增溶被开发并且治疗效果得到改善。在这项工作中，使用乳液溶剂扩散法制备了掺有1-丁基.3-甲基咪唑六氟磷酸酯，壳聚糖修饰的亚微米级聚（DL-丙交酯-乙交酯）（PLGA）纳米粒子（NP）。生物膜感染。使用表面活性剂（如Tween-80和poloxamer-188）制备的结合有IL的PLGA NP对生物膜下的细菌细胞显示出很高的抗菌活性。此外，通过暗场扫描透射电镜结合简单的样品预处理方法揭示了掺有IL的PLGA NP的抗菌机理。我们使用结合了IL的PLGA NP建立了一种药物递送系统，以增强聚合物纳米载体治疗生物膜感染的潜力。

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  • 来源
    《Materials science & engineering》 |2019年第4期|78-83|共6页
  • 作者

    Takahashi Chisato; Hattori Yuji; Yagi Shinya; Murai Takaaki; Takai Chika; Ogawa Noriko; Tanemura Masaki; Fuji Masayoshi; Kawashima Yoshiaki; Yamamoto Hiromitsu;

  • 作者单位

    Aichi Gakuin Univ, Pharmaceut Engn, Sch Pharm, Chikusa Ku, 1-100,Kusumoto Cho, Nagoya, Aichi 4648650, Japan;

    Aichi Gakuin Univ, Pharmaceut Engn, Sch Pharm, Chikusa Ku, 1-100,Kusumoto Cho, Nagoya, Aichi 4648650, Japan;

    Nagoya Univ, Inst Mat & Syst Sustainabil, Chikusa Ku, Furo Cho, Nagoya, Aichi 4648601, Japan;

    Aichi Synchrotron Radiat Ctr, 250-3 Minamiyamaguchi Cho, Seto, Aichi 4890965, Japan;

    Nagoya Inst Technol, Adv Ceram Res Ctr, 3-101-1,Honmachi, Tajimi, Gifu 5070033, Japan;

    Aichi Gakuin Univ, Pharmaceut Engn, Sch Pharm, Chikusa Ku, 1-100,Kusumoto Cho, Nagoya, Aichi 4648650, Japan;

    Nagoya Inst Technol, Dept Frontier Mat, Showa Ku, Nagoya, Aichi 4668555, Japan;

    Nagoya Inst Technol, Adv Ceram Res Ctr, 3-101-1,Honmachi, Tajimi, Gifu 5070033, Japan;

    Aichi Gakuin Univ, Pharmaceut Engn, Sch Pharm, Chikusa Ku, 1-100,Kusumoto Cho, Nagoya, Aichi 4648650, Japan;

    Aichi Gakuin Univ, Pharmaceut Engn, Sch Pharm, Chikusa Ku, 1-100,Kusumoto Cho, Nagoya, Aichi 4648650, Japan;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Ionic liquid; PLGA; Drug delivery system; Antibacterial activity; Electron microscopy; NEXAFS;

    机译：离子液体;PLGA;给药系统;抗菌活性;电子显微镜;NEXAFS;

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