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Antibacterial bone substitute of hydroxyapatite and magnesium oxide to prevent dental and orthopaedic infections

机译：羟基磷灰石和氧化镁的抗菌骨替代品，可预防牙齿和骨科感染

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摘要

Bone substitutes market is growing due to the great demand for bone regenerative therapies. However, most of the actual products available in the market are incapable of inhibiting bacterial colonization, which can lead to tissue infection and possible implant failure. Some bone substitutes are combined with antibiotics to avoid the development of implant-associated infections, but the growing bacterial resistance to antibiotics often makes these products ineffective. Therefore, it is mandatory to develop new and alternative approaches. In the present work, a granular bone substitute of hydroxyapatite was produced, where different percentages of magnesium oxide were introduced. The antibacterial activity and biofilm formation was evaluated towards Staphylococcus aureus and Escherichia coli. The inclusion of magnesium oxide particles reduced bacterial growth and biofilm formation in a concentration-dependent manner, when compared with pure hydroxyapatite materials. Superior antibacterial activity and inhibition of biofilm formation was observed for Staphylococcus aureus with complete eradication when magnesium oxide percentages were equal or above 3 wt%. The materials cytotoxicity was assessed under ISO 10993-5:2009 guidance and through Live/Dead cell marking and none of the produced granules was cytotoxic. In addition, reactive oxygen species production was also evaluated and the results revealed that the exposure to the materials extracts did not induce the formation of reactive oxygen species by cells.
机译：由于对骨再生疗法的巨大需求，骨替代品市场正在增长。但是，市场上可用的大多数实际产品均不能抑制细菌定植，这可能导致组织感染和可能的植入失败。一些骨替代品与抗生素结合使用可以避免植入物相关感染的发生，但是细菌对抗生素的耐药性不断提高，常常使这些产品无效。因此，必须开发新的替代方法。在目前的工作中，生产了羟基磷灰石的颗粒状骨替代物，其中引入了不同百分比的氧化镁。评价了对金黄色葡萄球菌和大肠杆菌的抗菌活性和生物膜形成。与纯羟基磷灰石材料相比，包含氧化镁颗粒以浓度依赖性的方式减少了细菌的生长和生物膜的形成。当氧化镁百分比等于或大于3 wt％时，金黄色葡萄球菌具有优异的抗菌活性和对生物膜形成的抑制作用，可完全消除。在ISO 10993-5：2009指导下并通过活/死细胞标记评估了材料的细胞毒性，所产生的颗粒均无细胞毒性。另外，还评估了活性氧的产生，结果表明暴露于原料提取物不会诱导细胞形成活性氧。

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  • 来源
    《Materials science & engineering》 |2019年第4期|529-538|共10页
  • 作者

    Coelho Catarina C.; Araujo Rita; Quadros Paulo A.; Sousa Susana R.; Monteiro Fernando J.;

  • 作者单位

    Univ Porto, I3S Inst Invest & Inovacao Saude, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Univ Porto, INEB Inst Engn Biomed INEB, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Univ Porto, FEUP Fac Engn Univ Porto, Rua Dr Roberto Arias S-N, P-4200465 Porto, Portugal|FLUIDINOVA SA, Rua Engenheiro Frederico Ulrich 2650, P-4470605 Moreira Da Maia, Portugal;

    Univ Porto, I3S Inst Invest & Inovacao Saude, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Univ Porto, INEB Inst Engn Biomed INEB, Rua Alfredo Allen 208, P-4200135 Porto, Portugal;

    FLUIDINOVA SA, Rua Engenheiro Frederico Ulrich 2650, P-4470605 Moreira Da Maia, Portugal;

    Univ Porto, I3S Inst Invest & Inovacao Saude, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Univ Porto, INEB Inst Engn Biomed INEB, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Inst Politecn Porto, ISEP Inst Super Engn Porto, Rua Dr Antonio Bernardino de Almeida 431, P-4200072 Porto, Portugal;

    Univ Porto, I3S Inst Invest & Inovacao Saude, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Univ Porto, INEB Inst Engn Biomed INEB, Rua Alfredo Allen 208, P-4200135 Porto, Portugal|Univ Porto, FEUP Fac Engn Univ Porto, Rua Dr Roberto Arias S-N, P-4200465 Porto, Portugal;

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  • 正文语种 eng
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  • 关键词

    Biomaterials; Antibacterial; Hydroxyapatite; Magnesium oxide; Bone substitute; Implant-associated infections;

    机译：生物材料抗菌羟基磷灰石氧化镁骨替代物植入相关感染;

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