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首页> 外文期刊>Materials science & engineering >Encapsulation of geranyl cinnamate in polycaprolactone nanoparticles
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Encapsulation of geranyl cinnamate in polycaprolactone nanoparticles

机译：肉桂酸香叶酯在聚己内酯纳米颗粒中的包封

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摘要

Geranyl cinnamate is an ester derived from natural compounds that has excellent antibacterial properties but is susceptible to degradation in the presence of oxygen, light, heat, moisture and other aggressive agents, making it unstable. In this work, the encapsulation of geranyl cinnamate in polycaprolactone (PCL) nanoparticles and its antibacterial properties towards Escherichia coil and Staphylococcus aureus were investigated. PCL nanoparticles loaded with geranyl cinnamate were obtained by a miniemulsification/solvent evaporation technique resulting in spherical nanoparticles with an average diameter of 177.6 nm. TGA showed that geranyl cinnamate evaporation was retarded at 20 degrees C after encapsulation. Aqueous dispersions of geranyl cinnamate-loaded PCL nanoparticles stored at 4 degrees C presented good colloidal stability over 60 days. Minimum inhibitory concentration (MIC) tests showed that geranyl cinnamate was not released from the PCL nanoparticles in aqueous solution even after 72 h, requiring the use of a trigger (e.g. oil phase, lipase to degrade the polymer matrix) to release the active compound.
机译：香叶酸香叶酯是衍生自天然化合物的酯，具有出色的抗菌性能，但在氧气，光，热，湿气和其他侵蚀性试剂的存在下易于降解，使其不稳定。在这项工作中，研究了聚己内酯（PCL）纳米颗粒中香叶酸香叶基酯的封装及其对大肠杆菌和金黄色葡萄球菌的抗菌性能。通过微乳化/溶剂蒸发技术获得负载有香叶酸香叶基酯的PCL纳米颗粒，得到平均直径为177.6nm的球形纳米颗粒。 TGA显示在封装后，香叶酸香叶酯的蒸发在20℃下被延迟。储存在4摄氏度的肉桂酸香叶基酯负载的PCL纳米颗粒的水分散液在60天内表现出良好的胶体稳定性。最小抑菌浓度（MIC）测试表明，即使在72小时后，肉桂酸香叶酯也不会从水溶液中的PCL纳米颗粒中释放出来，需要使用引发剂（例如油相，脂肪酶降解聚合物基质）来释放活性化合物。

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