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Preparation and properties of carbon nanotube (Fe)/hydroxyapatite composite as magnetic targeted drug delivery carrier

机译：碳纳米管（Fe）/羟基磷灰石复合材料作为磁性靶向药物输送载体的制备及性能

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摘要

A novel magnetic targeted drug delivery carrier based on a carbon nanotube (Fe)/hydroxyapatite (CNT(Fe)/HA) composite was successfully fabricated by an in situ synthesis of CNTs in HA nanopowder using Fe catalysts and subsequent chemical modification of the as-fabricated CNT(Fe)/HA by chitosan (CS) and folic acid (FA) for a controllable release of an anticancer drug doxorubicin (DOX). The synthesized CNTs, Fe, and HA self-assembled into a composite structure in situ during the synthesis. After the acid treatment, the CNTs were shorter and homogeneously dispersed, the tips of the CNTs were opened, and oxygen-containing functional groups were introduced onto the CNTs. Upon the functional modification through the surface coating with CS and FA, the functionalized CNT(Fe)/HA became capable of loading DOX through both pi-pi stacking and electrostatic adsorption of FA. The results showed that the average drug-loading rate of DOX was 130 wt%. Furthermore, the pH response of FA-CS-CNT(Fe)/HA enabled the release of a large amount of DOX in phosphate-buffered saline (PBS) at pH = 5.5 with an average drug release rate of 52 wt% after 72 h. In contrast, the drug release in PBS at pH = 7.4 was only 8 wt%. In addition, the saturation magnetization, coercive force, and remanence to saturation magnetization ratio of DOX-FA-CS-CNT(Fe)/HA were 0.88 emu g(-1), 668.96 Oe, and 0.44, respectively, indicating its potential for drug transport under strong external magnetic fields, which could enable magnetic targeted delivery.
机译：通过使用铁催化剂在HA纳米粉中原位合成碳纳米管并随后对其化学修饰，成功地制备了基于碳纳米管（Fe）/羟基磷灰石（CNT（Fe）/ HA）复合材料的新型磁性靶向药物输送载体。壳聚糖（CS）和叶酸（FA）制备的CNT（Fe）/ HA用于可控释放的抗癌药阿霉素（DOX）。合成的CNT，Fe和HA在合成过程中原位自组装成复合结构。酸处理后，CNT变短且均匀分散，CNT的尖端被打开，并且含氧官能团被引入到CNT上。通过使用CS和FA进行表面涂层的功能改性后，功能化的CNT（Fe）/ HA能够通过pi-pi堆叠和FA的静电吸附来加载DOX。结果表明，DOX的平均载药率为130 wt％。此外，FA-CS-CNT（Fe）/ HA的pH响应使得能够在pH = 5.5的磷酸盐缓冲盐水（PBS）中释放大量DOX，72小时后平均药物释放率为52 wt％ 。相反，在pH = 7.4的PBS中药物释放仅为8 wt％。另外，DOX-FA-CS-CNT（Fe）/ HA的饱和磁化强度，矫顽力和剩磁与饱和磁化强度之比分别为0.88 emu g（-1），668.96 Oe和0.44。在强外部磁场下进行药物运输，可以实现磁性靶向递送。

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  • 来源
    《Materials science & engineering》 |2019年第4期|222-229|共8页
  • 作者

    Li Haipeng; Sun Xiwen; Li Yuanjun; Li Baoe; Liang Chunyong; Wang Hongshui;

  • 作者单位

    Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China|Hebei Univ Technol, Res Inst Energy Equipment Mat, Tianjin 300130, Peoples R China;

    Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China;

    Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China;

    Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China;

    Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China|Hebei Univ Technol, Res Inst Energy Equipment Mat, Tianjin 300130, Peoples R China;

    Hebei Univ Technol, Sch Mat Sci & Engn, Tianjin 300130, Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Drug delivery carrier; Carbon nanotube (Fe)/hydroxyapatite composite; Controlled release; Magnetic property;

    机译：药物输送载体;碳纳米管（Fe）/羟基磷灰石复合材料;控释;磁性;

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