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首页> 外文期刊>Materials science & engineering >Controlling burst effect with PLA/PVA coaxial electrospun scaffolds loaded with BMP-2 for bone guided regeneration
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Controlling burst effect with PLA/PVA coaxial electrospun scaffolds loaded with BMP-2 for bone guided regeneration

机译：装有BMP-2的PLA / PVA同轴电纺支架控制爆破效果，以促进骨引导再生

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Biocompatible scaffolds have been used to promote cellular growth and proliferation in order to develop grafts, prostheses, artificial skins and cartilage. Electrospinning is widely studied as a method capable of producing nanofibers which enables cell attachment and proliferation, generating a functional scaffold that is suitable for many types of organs or tissues. In this study, electrospinning was used to obtain core-shell and monolithic fibers from the biocompatible poly (lactic acid) and poly (vinyl alcohol) polymers. The main purpose of this work is to produce core-shell nanofiber based scaffolds that works as a sustained delivery vehicle for BMP-2 protein, allowing those fibers to be used in the recovery of alveolar bone tissue without further bone surgery. Then, polymer nanofibers were manufactured by optimizing process parameters of coaxial electrospinning with emphasis on the most relevant ones: voltage, internal and external flows in an attempt to correlate fibers properties with protein releasing abilities. All nanofibers were characterized according to its morphology, thermal behaviour, crystallinity and release profile. For the release tests, bovine albumin was added into internal fiber for future periodontal restorage application. Obtained results demonstrate that fibers were formed with diameters up to 250 nm. According to electronic microscopy images, one could observe surface of nanofibers, thickness and core-shell morphology confirmed. X-ray diffraction analysis and contact angle tests showed fibers with low crystal degree and low hydrophobicity. Nanofibers structure affected in vitro release model tests and consequently the cellular assays.
机译：生物相容性支架已被用于促进细胞生长和增殖，以发展出移植物，假体，人造皮肤和软骨。静电纺丝作为能够生产能够使细胞附着和增殖的纳米纤维的方法被广泛地研究，从而产生适用于许多类型的器官或组织的功能性支架。在这项研究中，静电纺丝被用来从生物相容性聚（乳酸）和聚（乙烯醇）聚合物中获得核壳和整体纤维。这项工作的主要目的是生产基于核-壳纳米纤维的支架，该支架可作为BMP-2蛋白的持续递送载体，使这些纤维无需进一步的骨外科手术即可用于牙槽骨组织的恢复。然后，通过优化同轴电纺丝的工艺参数，重点是最相关的参数来制造聚合物纳米纤维：电压，内部和外部流动，以使纤维性能与蛋白质释放能力相关联。所有纳米纤维都根据其形态，热性能，结晶度和释放特性进行了表征。对于释放测试，将牛白蛋白添加到内部纤维中，以用于将来的牙周修复。所得结果表明，形成的纤维直径最大为250 nm。根据电子显微镜图像，可以观察到纳米纤维的表面，厚度和核壳形态。 X射线衍射分析和接触角测试表明纤维具有低结晶度和低疏水性。纳米纤维的结构影响体外释放模型测试，并因此影响细胞测定。

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