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首页> 外文期刊>Materials science & engineering >Eco-friendly synthesized spherical ZnO materials: Effect of the core-shell to solid morphology transition on antimicrobial activity
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Eco-friendly synthesized spherical ZnO materials: Effect of the core-shell to solid morphology transition on antimicrobial activity

机译：环保型合成球形ZnO材料：核-壳向固体形态转变对抗菌活性的影响

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摘要

ZnO materials with spherical morphology, core-shell and solid, disperse or interconnected, were obtained by a completely green synthesis via a carbohydrate-template route. Morphology, structure and optical properties, as well as antimicrobial potential and cytocompatibility were investigated. The antimicrobial efficiency of the obtained materials was screened against a large spectrum of reference and clinical microbial strains, both susceptible and exhibiting resistance phenotypes of clinical and epidemiological interest, in planktonic and biofilm state. Their biocidal activity is strongly dependent of material's characteristics and target microorganism. One of the most valuable findings of our study is the good antibiofilm activity of the obtained nanostructures, which in some cases was superior to that noted against planktonic cells, despite the well-known high tolerance of biofilm-embedded cells to different stressor agents. Another important finding is the excellent efficiency against three Gram-negative, respectively Pseudomonas aeruginosa, Acinetobacter baumannii, and Klebsiella pneumortiae and two Gram-positive species, ie. Staphylococcus aureus and Enteroccus faecium included in the ESKAPE list of the most dangerous resistant pathogens, requiring global surveillance and urgent need for the development of novel antimicrobial agents. Our study offers the first insight regarding the high therapeutic potential of ZnO nano particles against the fearful nosocomial pathogen A. baumannii. The cytocompatibility of the developed materials in terms of cell morphology, viability and proliferation, revealed a comparable dose-dependent cellular response, at the active antimicrobial concentrations, only a low effect on cell viability is evidenced. Overall, our data demonstrated the potential of the materials for antimicrobial applications and also that their biotoxicity can be modulated directly through their morpho-structural characteristics.
机译：具有球形形态，核-壳和固体，分散或相互连接的ZnO材料是通过碳水化合物模板路线通过完全绿色合成获得的。研究了形态，结构和光学性质，以及抗菌潜力和细胞相容性。针对浮游生物和生物膜状态下的敏感和表现出临床和流行病学意义的耐药表型的大范围参考和临床微生物菌株，筛选了获得的材料的抗菌效率。它们的杀生物活性在很大程度上取决于材料的特性和目标微生物。我们研究中最有价值的发现之一是获得的纳米结构具有良好的抗生物膜活性，尽管众所周知，生物膜包埋的细胞对不同的应激因子具有很高的耐受性，但在某些情况下，它的抗生物膜活性优于浮游细胞。另一个重要发现是对三种革兰氏阴性菌（铜绿假单胞菌，鲍曼不动杆菌和肺炎克雷伯菌）和两种革兰氏阳性菌（即革兰氏阳性菌）的优异疗效。金黄色葡萄球菌和粪肠球菌被列入ESKAPE最危险的抗药性病原体清单，需要进行全球监测，并且迫切需要开发新型抗菌剂。我们的研究提供了有关ZnO纳米颗粒对可怕的医院病原体鲍曼不动杆菌的高治疗潜力的第一见解。在细胞形态，活力和增殖方面，已开发材料的细胞相容性表明，在活性抗菌剂浓度下，具有相当的剂量依赖性细胞反应，但对细胞活力的影响却很小。总体而言，我们的数据证明了该材料在抗菌应用中的潜力，并且其生物毒性可以通过其形态结构特征直接进行调节。

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  • 来源
    《Materials science & engineering》 |2019年第4期|438-450|共13页
  • 作者

    Patrinoiu Greta; Hussien Mohammed Dyia; Calderon-Moreno Jose Maria; Atkinson Irina; Musuc Adina M.; Ion Raluca N.; Cimpean Anisoara; Chifiriuc Mariana C.; Carp Oana;

  • 作者单位

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, Spl Independentei 202, Bucharest 060021, Romania;

    Univ Bucharest, Res Inst, Fac Biol, Dept Microbiol,ICUB, Ale Portocalilor 1-3, Bucharest 60101, Romania;

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, Spl Independentei 202, Bucharest 060021, Romania;

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, Spl Independentei 202, Bucharest 060021, Romania;

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, Spl Independentei 202, Bucharest 060021, Romania;

    Univ Bucharest, Res Inst, Fac Biol, Dept Microbiol,ICUB, Ale Portocalilor 1-3, Bucharest 60101, Romania;

    Univ Bucharest, Res Inst, Fac Biol, Dept Microbiol,ICUB, Ale Portocalilor 1-3, Bucharest 60101, Romania;

    Univ Bucharest, Res Inst, Fac Biol, Dept Microbiol,ICUB, Ale Portocalilor 1-3, Bucharest 60101, Romania;

    Romanian Acad, Ilie Murgulescu Inst Phys Chem, Spl Independentei 202, Bucharest 060021, Romania;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Antibacterial activity; Carbohydrates; Green chemistry; ZnO;

    机译：抗菌活性;碳水化合物;绿色化学;ZnO;

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