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The design strategy of intelligent biomedical magnesium with controlled-release platform

机译：控释平台智能生物医学镁的设计策略

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摘要

Magnesium has a very promising adhibition in biomedical field for its excellent mechanical and biodegradable properties, however, the intelligent applications of biomedical magnesium developed difficultly due to its characteristic degradation. A intelligent biomedical magnesium was constructed on magnesium (Mg) surface by incorporating polydopamine (PD) and mechanized hollow mesoporous silica nanoparticles (HMSs) as smart delivery platform nanocontainers. The supramolecular nanovalves of mechanized HMSs consisted of alginate/ chitosan multilayers by self-assembly, which are capable of entrapping rhodamine 6G in the mesopores and can release the cargo under the chemical environment of alkali or Mg iron stimuli that correspond to the degradation of biomedical Mg. The alkali/Mg2+ dual stimuli-responsive release property of the HMSs endows the biodegradable Mg with controlled release potential. The well-designed smart delivery nanocontainers were combined with polydopamine deposited on Mg for excellent adhesion properties and positively charged amino group of PD. Furthermore, when the biomedical Mg with these mechanized HMSs was degraded in the simulated body environment, the alkali/Mg2+-triggered release of cargos from this smart delivery platform could bring a more functional application.
机译：镁因其优异的机械和可生物降解特性而在生物医学领域具有非常广阔的前景，然而，由于其特性退化，生物医学镁的智能应用难以开发。通过将聚多巴胺（PD）和机械化的中空介孔二氧化硅纳米粒子（HMS）结合起来作为智能的传递平台纳米容器，在镁（Mg）表面上构建了一种智能生物医学镁。机械化HMS的超分子纳米阀由藻酸盐/壳聚糖通过自组装多层组成，能够将罗丹明6G捕获在中孔中，并且可以在碱或Mg铁刺激的化学环境下释放货物，这对应于生物医学Mg的降解。 HMS的碱/ Mg 2+双重刺激响应释放特性赋予可生物降解的Mg以受控的释放潜力。精心设计的智能递送纳米容器与沉积在Mg上的聚多巴胺结合使用，具有出色的粘合性能和PD的带正电荷的氨基。此外，当带有这些机械化HMS的生物医学Mg在模拟的人体环境中降解时，碱/ Mg2 +触发的从该智能交付平台释放的货物会带来更多的功能应用。

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  • 来源
    《Materials science & engineering》 |2019年第4期|254-263|共10页
  • 作者

    Bi Yanze; Zhu Xinyun; Zhao Jianliang; Cui Hanrui; Wang Zhenguo; Li Yan; Wang Cai-qi;

  • 作者单位

    Beihang Univ, Sch Mat Sci & Engn, Beijing 100191, Peoples R China|Beihang Univ, Minist Educ, Key Lab Aerosp Adv Mat & Performance, Beijing 100191, Peoples R China|Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100191, Peoples R China;

    Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China;

    Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China;

    Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China;

    Beihang Univ, Sch Mat Sci & Engn, Beijing 100191, Peoples R China|Beihang Univ, Minist Educ, Key Lab Aerosp Adv Mat & Performance, Beijing 100191, Peoples R China|Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100191, Peoples R China;

    Beihang Univ, Sch Mat Sci & Engn, Beijing 100191, Peoples R China|Beihang Univ, Minist Educ, Key Lab Aerosp Adv Mat & Performance, Beijing 100191, Peoples R China|Beihang Univ, Beijing Adv Innovat Ctr Biomed Engn, Beijing 100191, Peoples R China;

    Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Magnesium; Polydopamine; Hollow mesoporous silica; Controlled release; Alginate; Chitosan;

    机译：镁;聚多巴胺;空心中孔二氧化硅;控释;藻酸盐;壳聚糖;

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