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首页> 外文期刊>Materials science & engineering >Antibacterial investigation of titanium-copper alloys using luminescent Staphylococcus epidermidis in a direct contact test
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Antibacterial investigation of titanium-copper alloys using luminescent Staphylococcus epidermidis in a direct contact test

机译：直接接触试验中发光的表皮葡萄球菌对钛铜合金的抗菌作用研究

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摘要

Commercially pure titanium (CP-Ti), used as oral implants, is often populated by various bacterial colonies in the oral cavity. These bacteria can cause Peri-implantitis, leading to loss of bone tissue and failure of implants. With the increased awareness of antibiotic resistance, research has been directed towards alternative solutions and recent findings have indicated titanium-copper (Ti-Cu) alloys as a promising antibacterial material. The aim of this study was to produce homogeneous Ti-Cu alloys, with various concentrations of copper, and to characterise their antibacterial properties through direct contact tests, using luminescent bacteria, in addition to traditional materials characterisation techniques.Samples of CP-Ti and four different Ti-Cu alloys (1, 2.5, 3 and 10 wt%Cu) were produced in an arc-furnace, heated treated and rapidly quenched.X-ray diffraction revealed that Ti2Cu, was present only in the 10 wt%Cu alloy, however, scanning electron microscopy (SEM) indicated precipitates at the grain boundaries of the 3 wt%Cu alloy, which were confirmed to be of a copper rich phase by energy dispersive x-ray spectroscopy (EDS) analysis. EDS line scans confirmed that the alloys were homogenous. After 6 h, a trend between copper content and antibacterial rate could be observed, with the 10 wt%Cu alloy having the highest rate. SEM confirmed fewer bacteria on the 3 wt%Cu and especially the 10 wt%Cu samples.Although the 10 wt%Cu alloy gave the best antibacterial results, it is desired that the Cu concentration is below similar to 3 wt%Cu to maintain similar mechanical and corrosive performance as CP-Ti. Therefore, it is proposed that future work focuses on the 3 wt%Cu alloy.
机译：用作口腔植入物的商业纯钛（CP-Ti）通常在口腔中充满各种细菌菌落。这些细菌可引起种植体周围炎，导致骨组织损失和植入物失效。随着对抗生素抗性认识的提高，研究已转向替代解决方案，最近的发现表明钛铜（Ti-Cu）合金是一种有前途的抗菌材料。这项研究的目的是生产具有不同浓度铜的均质Ti-Cu合金，并通过除传统材料表征技术外的使用发光细菌的直接接触测试，通过抗菌测试来表征其抗菌性能.CP-Ti和四种样品在电弧炉中生产了不同的Ti-Cu合金（1、2.5、3和10 wt％Cu），经过热处理和快速淬火.X射线衍射表明Ti2Cu仅存在于10wt％Cu合金中，然而，扫描电子显微镜（SEM）表明在3wt％Cu合金的晶界处有沉淀，通过能量色散X射线光谱法（EDS）分析证实其为富铜相。 EDS线扫描证实合金是均匀的。 6小时后，可观察到铜含量和抗菌率之间的趋势，其中10wt％Cu合金具有最高的率。 SEM证实了3 wt％Cu样品上细菌的减少，尤其是10 wt％Cu样品上的细菌较少。尽管10 wt％Cu合金具有最佳的抗菌效果，但希望Cu浓度低于3 wt％Cu才能保持相似机械性能和腐蚀性表现为CP-Ti。因此，建议将来的工作集中在3wt％Cu合金上。

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  • 来源
    《Materials science & engineering》 |2019年第4期|707-714|共8页
  • 作者

    Fowler Lee; Janson Oscar; Engqvist Hakan; Norgren Susanne; Ohman-Magi Caroline;

  • 作者单位

    Uppsala Univ, Div Appl Mat Sci, Dept Engn Sci, Angstrom Lab, Box 534, S-75121 Uppsala, Sweden;

    Uppsala Univ, Div Appl Mat Sci, Dept Engn Sci, Angstrom Lab, Box 534, S-75121 Uppsala, Sweden;

    Uppsala Univ, Div Appl Mat Sci, Dept Engn Sci, Angstrom Lab, Box 534, S-75121 Uppsala, Sweden;

    Uppsala Univ, Div Appl Mat Sci, Dept Engn Sci, Angstrom Lab, Box 534, S-75121 Uppsala, Sweden;

    Uppsala Univ, Div Appl Mat Sci, Dept Engn Sci, Angstrom Lab, Box 534, S-75121 Uppsala, Sweden;

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  • 正文语种 eng
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  • 关键词

    Copper; Titanium; Antibacterial; S. epidermidis; Ti2Cu;

    机译：铜;钛;抗菌;硫表皮;钛铜;

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