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首页> 外文期刊>Materials science & engineering >Elastomeric biocomposite of silver-containing mesoporous bioactive glass and poly(1,8-octanediol citrate): Physiochemistry and in vitro antibacterial capacity in tissue engineering applications
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Elastomeric biocomposite of silver-containing mesoporous bioactive glass and poly(1,8-octanediol citrate): Physiochemistry and in vitro antibacterial capacity in tissue engineering applications

机译：含银的介孔生物活性玻璃和聚（1,8-辛二醇柠檬酸酯）的弹性生物复合材料：组织工程应用中的理化和体外抗菌能力

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摘要

A novel series of silver-doped mesoporous bioactive glass/poly(1,8-octanediol citrate) (AgMBG/POC) elastomeric biocomposite scaffolds were successfully constructed by a salt-leaching technique for the first time and the effect of inclusion of different AgMBG contents (5, 10, and 20 wt%) on physicochemical and biological properties of pure POC elastomer was evaluated. Results indicated that AgMBG particles were uniformly dispersed in the POC matrix and increasing the AgMBG concentration into POC matrix up to 20 wt% enhanced thermal behaviour, mechanical properties and water uptake ability of the composite scaffolds compared to those from POC. The 20%AgMBG/POC additionally showed higher degradation rate in Tris(hydroxymethyl)-aminomethane-HCl (Tris-HCl) compared with pure POC and lost about 26% of its initial weight after soaking for 28 days. The AgMBG phase incorporation also significantly endowed the resulting composite scaffolds with efficient antibacterial properties against Escherichia coli and Staphylococcus aureus bacteria while preserving their favorable biocompatibility with soft tissue cells (ie., human dermal fibroblast cells). Taken together, our results suggest that the synergistic effect of both AgMBG and POC make these newly designed AgMBG/POC composite scaffold an attractive candidate for soft tissue engineering applications.
机译：首次通过盐浸技术成功地构建了新型的掺银介孔生物活性玻璃/聚（1,8-辛二醇柠檬酸酯）（AgMBG / POC）弹性生物复合支架，并研究了包含不同AgMBG含量的影响评估了纯POC弹性体的理化和生物学性能（5、10和20 wt％）。结果表明，与来自POC的那些相比，AgMBG颗粒均匀地分散在POC基质中，并且将AgMBG的浓度增加到POC基质中高达20wt％，增强了复合支架的热性能，机械性能和吸水能力。与纯POC相比，20％AgMBG / POC在Tris（羟甲基）-氨基甲烷-HCl（Tris-HCl）中的降解速率更高，浸泡28天后其初始重量减少了约26％。 AgMBG相的掺入还显着赋予所得的复合支架对大肠杆菌和金黄色葡萄球菌细菌有效的抗菌性能，同时保留它们与软组织细胞（即人真皮成纤维细胞）的良好生物相容性。两者合计，我们的结果表明，AgMBG和POC的协同作用使这些新设计的AgMBG / POC复合支架成为软组织工程应用的有吸引力的候选者。

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