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首页> 外文期刊>Materials science & engineering >Wavy small-diameter vascular graft made of eggshell membrane and thermoplastic polyurethane
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Wavy small-diameter vascular graft made of eggshell membrane and thermoplastic polyurethane

机译：由蛋壳膜和热塑性聚氨酯制成的波浪形小直径血管移植物

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摘要

In this study, a small-diameter, double-layered eggshell membrane/thermoplastic polyurethane (ESM/TPU) vascular graft with a wavy structure was developed. The avian eggshell membrane, a fibrous structure similar to the extracellular matrix (ECM), has the potential to yield rapid endothelialization in vitro. The dopamine and heparin modification of the ESM surface not only promoted human umbilical vein endothelial cell (HUVEC) proliferation via cytocompatibility assessment, but also improved its anticoagulation properties as verified in platelet adhesion tests. The biomimetic mechanical properties of the vascular graft were provided by the elastic TPU fibers via electrospinning using a wavy cross-section rotating collector. The advantage of combining these two materials is to make use of the bioactivity of ESM as the internal membrane and the tunable mechanical properties of TPU as the external layer. The circumferentially wavy structure of the vascular graft produced a toe region in the non-linear section of the stress strain curve similar to that of natural blood vessels. The ESM/TPU graft's circumferential ultimate strength was 2.57 MPa, its strain was 339% mm/mm, and its toe region was found to be around 20% mm/mm. Cyclical tension tests showed that the vascular graft could maintain good mechanical properties and showed no structural damage under repeated extension tests.
机译：在这项研究中，开发了一种具有波浪结构的小直径双层蛋壳膜/热塑性聚氨酯（ESM / TPU）血管移植物。禽蛋壳膜是一种类似于细胞外基质（ECM）的纤维结构，具有在体外产生快速内皮化的潜力。通过细胞相容性评估，ESM表面的多巴胺和肝素修饰不仅促进了人脐静脉内皮细胞（HUVEC）的增殖，而且还改善了其抗凝特性，这在血小板粘附试验中得到了证实。血管移植物的仿生机械性能是由弹性TPU纤维通过使用波浪形横截面旋转收集器的电纺丝提供的。结合这两种材料的优点是利用ESM的生物活性作为内膜，并利用TPU的可调机械性能作为外层。血管移植物的圆周波纹结构在应力应变曲线的非线性部分产生了一个趾部区域，类似于自然血管。 ESM / TPU接枝的周向极限强度为2.57 MPa，应变为339％mm / mm，脚趾区域约为20％mm / mm。循环拉伸试验表明，在反复拉伸试验下，血管移植物可以保持良好的机械性能，并且没有结构破坏。

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