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首页> 外文期刊>Materials science & engineering >Characterization of breast tissue permeability for detection of vascular breast tumors: An in vitro study
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Characterization of breast tissue permeability for detection of vascular breast tumors: An in vitro study

机译：表征乳腺组织通透性以检测血管性乳腺肿瘤：一项体外研究

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摘要

The biological tissue could be considered as a porous matrix filled with the interstitial fluid. The tumoral tissue has a different permeability from the healthy tissue. With regard to this knowledge, the main objective of the present study is to study the tissue permeability as a diagnostic parameter for the detection of breast cancer. To this end, the healthy and the cancerous specimens of the breast tissue are taken from 17 female cases. All cancerous tumors are in the vascular phase of the growth. The samples undergo a uniaxial compression test by a robotic system while the strain rate is set to remain unchanged. Using the stress and the strain rate data, the strain-dependent permeability is determined, which is an exponential function of the strain level. The permeability function is identified by the initial permeability at the zero compressive strain and a material constant. Results show that the initial permeability of the healthy breast tissue is significantly different from the corresponding value for the cancerous tissue. For all cancerous samples, the permeability is less than the healthy tissue samples; as 40-70% reduction in the initial permeability is observed compared to the healthy breast tissue. The evaluation of the permeability between the healthy and the cancerous specimens is accompanied by the biopsy reports and observing structural images of the specimens using environmental scanning electron microscope. Based on the results, the permeability is suggested to have a diagnostic application for the detection of vascular breast tumors.
机译：可以将生物组织视为充满组织液的多孔基质。肿瘤组织具有与健康组织不同的渗透性。关于这一知识，本研究的主要目的是研究组织渗透性作为检测乳腺癌的诊断参数。为此，从17例女性病例中获取了健康和癌变的乳腺组织标本。所有癌性肿瘤均处于血管生长阶段。样品通过机械手系统进行单轴压缩测试，而应变率设置为保持不变。使用应力和应变率数据，确定应变相关的渗透率，它是应变水平的指数函数。渗透率函数由零压缩应变下的初始渗透率和材料常数确定。结果表明，健康乳腺组织的初始渗透率与癌组织的相应值显着不同。对于所有癌性样品，通透性均小于健康组织样品。与健康的乳腺组织相比，观察到初始渗透率降低了40-70％。在健康标本和癌标本之间的渗透性评估中，将伴随有活检报告并使用环境扫描电子显微镜观察标本的结构图像。根据这些结果，建议通透性可用于检测血管性乳腺肿瘤。

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