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AgBiS_2 nanoparticles with synergistic photodynamic and bioimaging properties for enhanced malignant tumor phototherapy

机译：具有协同的光动力学和生物成像特性的AgBiS_2纳米粒子可增强恶性肿瘤光疗

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摘要

Bismuth (Bi)-based nanoagents for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) are attracting attention and are highly desired for malignant tumor diagnosis and treatment, but producing these materials is still a challenge. Here, we designed theranostic nanoparticles (NPs) based on AgBiS2 for computed tomography (CT) imaging and phototherapy of malignant tumors. These AgBiS2 NPs could effectively convert light into heat (with a high photothermal conversion efficiency of 36.51%) and significantly increase the generation of intracellular reactive oxygen species (ROS) under near infrared (NIR) laser irradiation. Remarkably, the combined PTT/PDT successfully inhibited the growth of a highly malignant osteosarcoma in vivo. In addition, AgBiS2 NPs exhibited an enhanced CT contrast ability for tumor imaging and killed clinically derived Staphylococcus aureus (S. aureus) to prevent infection. In conclusion the ability of AgBiS2 NPs to be used in phototherapy and CT imaging and their antibacterial abilities indicate that they are promising candidates for malignant tumor theranostics.
机译：用于协同光动力疗法（PDT）和光热疗法（PTT）的基于铋（Bi）的纳米剂引起了人们的注意，并且非常需要用于恶性肿瘤的诊断和治疗，但是生产这些材料仍然是一个挑战。在这里，我们设计了基于AgBiS2的治疗性纳米粒子（NP），用于计算机X线断层扫描（CT）成像和光疗性恶性肿瘤。这些AgBiS2 NP可以有效地将光转换为热（具有36.51％的高光热转换效率），并显着增加在近红外（NIR）激光照射下细胞内活性氧（ROS）的产生。值得注意的是，组合的PTT / PDT在体内成功抑制了高度恶性的骨肉瘤的生长。另外，AgBiS2 NP对肿瘤成像表现出增强的CT对比能力，并杀死了临床衍生的金黄色葡萄球菌（S. aureus）以防止感染。总之，AgBiS2 NPs用于光疗和CT成像的能力及其抗菌能力表明，它们是恶性肿瘤治疗学的有希望的候选者。

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  • 来源
    《Materials science & engineering》 |2020年第2期|110324.1-110324.9|共9页
  • 作者

    Cheng Jing; Wang Wanshun; Xu Xingyi; Lin Zefeng; Xie Chao; Zhang Yuxuan; Zhang Tao; Li Lihua; Lu Yao; Li Qi;

  • 作者单位

    Southern Med Univ Zhujiang Hosp Dept Orthoped 253 Gongye Rd Guangzhou 510282 Guangdong Peoples R China;

    Gen Hosp Southern Theater Command PLA Hosp Orthoped Key Lab Trauma & Tissue Repair Trop Area PLA Guangdong Key Lab Orthoped Technol & Implant Mat 111 Liuhua Rd Guangzhou 510010 Guangdong Peoples R China;

    South China Univ Technol State Key Lab Luminescent Mat & Devices Guangdong Prov Key Lab Fiber Laser Mat Sch Mat Sci & Engn Sch Phys 381 Wushan Rd Guangzhou 510640 Guangdong Peoples R China;

    Southern Med Univ Zhujiang Hosp Dept Orthoped 253 Gongye Rd Guangzhou 510282 Guangdong Peoples R China|Gen Hosp Southern Theater Command PLA Hosp Orthoped Key Lab Trauma & Tissue Repair Trop Area PLA Guangdong Key Lab Orthoped Technol & Implant Mat 111 Liuhua Rd Guangzhou 510010 Guangdong Peoples R China|Southern Med Univ Zhujiang Hosp Clin Res Ctr 253 Gongye Rd Guangzhou 510282 Guangdong Peoples R China;

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