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首页> 外文期刊>Materials science & engineering >Polycaprolactone nanofiber mats decorated with photoresponsive nanogels and silver nanoparticles: Slow release for antibacterial control
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Polycaprolactone nanofiber mats decorated with photoresponsive nanogels and silver nanoparticles: Slow release for antibacterial control

机译：聚己内酯纳米纤维垫，装饰有光响应性纳米凝胶和银纳米颗粒：缓释性，可用于抗菌控制

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摘要

Smart nanomaterials activated by light is one of the most exciting strategies to control the release of substances in varied environments. Here we developed a smart nanomaterial composed by a photoresponsive nanogel containing silver nanoparticles (AgNps) immobilized on the surface of biodegradable and biocompatible polycaprolactone (PCL) nanofibers mats produced by electrospinning. The AgNps are released from the nanogel and dispersed inside the nanofiber mats when this system is irradiated by light at 405 nm. This light excites the plasmonic band of the AgNps, which breaks the nanogel and, as a consequence, releases the AgNps on the nanofibers. Consequently, this AgNps release mechanism controls the propagation of silver ions by the application of light. Different configurations of antibacterial nanofibers mats, including neat PCL nanofibers and PCL nanofibers modified with AgNps-Nanogels and AgNps, excited by laser light at 405 nm, were investigated regarding antibacterial properties. The best result was achieved using PCL nanofiber mats functionalized with AgNps and AgNps-Nanogels after light exposure, which generated inhibition diameters of 2.6 +/- 0.3 mm and 1.8 +/- 0.5 mm for S. aureus and E. coli, respectively. The smart nanomaterial developed here is a promising material for clinical application as wound dressing activated by light.
机译：光激活的智能纳米材料是控制各种环境中物质释放的最令人兴奋的策略之一。在这里，我们开发了一种由光敏纳米凝胶组成的智能纳米材料，该纳米凝胶包含固定在通过电纺丝生产的可生物降解和生物相容性聚己内酯（PCL）纳米纤维垫表面上的银纳米颗粒（AgNps）。当该系统被405 nm的光照射时，AgNps从纳米凝胶中释放出来并分散在纳米纤维垫内。这种光激发了AgNps的等离子带，从而破坏了纳米凝胶，结果，在纳米纤维上释放了AgNps。因此，这种AgNps释放机制通过施加光来控制银离子的传播。研究了抗菌纳米纤维垫的不同结构，包括纯净的PCL纳米纤维和经AgNps-Nanogels和AgNps改性的PCL纳米纤维，它们在405 nm的激光激发下具有抗菌性能。最好的结果是，在暴露后，用AgNps和AgNps-Nanogels功能化的PCL纳米纤维毡可达到最佳效果，分别对金黄色葡萄球菌和大肠杆菌产生2.6 +/- 0.3 mm和1.8 +/- 0.5 mm的抑制直径。此处开发的智能纳米材料是光激活的伤口敷料，是一种有前途的临床应用材料。

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