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首页> 外文期刊>Materials science & engineering >Effect of TiO_2 doping on degradation rate, microstructure and strength of borate bioactive glass scaffolds
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Effect of TiO_2 doping on degradation rate, microstructure and strength of borate bioactive glass scaffolds

机译：TiO_2掺杂对硼酸盐生物活性玻璃支架降解速率，微观结构和强度的影响

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摘要

A titanium-containing borate glass series based on the system (52-X) B2O3-12CaO-6P(2)O(5)-14Na(2)O-16ZnO-XTiO2 with X varying from 0, 5 and 15 mol% of TiO2 incorporated, identified as BRT0, BRT1 and BRT3, respectively, were used in this study. Scaffolds (pore sizes, 165-230 mu m and porosity, 53.51-69.51%) were prepared using a polymer foam replication technique. BRT3 scaffolds exhibited higher compressive strength (7.16 +/- 0.22 MPa) when compared to BRT0 (6.02 +/- 0.47 MPa) and BRT1 (5.65 +/- 0.28 MPa) scaffolds with lower, or no, TiO2 content. The solubility of the scaffolds decreased as the TiO2 content increased up to 15 mol% when samples of each scaffold were immersed in DI water and the pH of all these extracts went up from 7.0 to 8.5 in 30 days. The cumulative ion release from the scaffolds showed significant difference with respect to TiO2 content; addition of 5 mol% TiO2 at the expense of borate (B2O3) decreased the ion release remarkably. Furthermore, it was found that for all three scaffolds, cumulative ion release increased with incubation time. The results indicate that the degradation rates and compressive strengths of borate bioactive glass scaffolds could be controlled by varying the amount of TiO2 incorporated, confirming their potential as scaffolds in TKA and rTKA.
机译：基于系统（52-X）B2O3-12CaO-6P（2）O（5）-14Na（2）O-16ZnO-XTiO2的含钛硼酸盐玻璃系列，X含量为0、5和15 mol％这项研究使用了掺入的TiO2，分别标识为BRT0，BRT1和BRT3。使用聚合物泡沫复制技术制备支架（孔径为165-230μm，孔隙率为53.51-69.51％）。与具有较低或没有TiO2含量的BRT0（6.02 +/- 0.47 MPa）和BRT1（5.65 +/- 0.28 MPa）支架相比，BRT3支架表现出更高的抗压强度（7.16 +/- 0.22 MPa）。当将每个支架的样品浸入去离子水中时，随着TiO2含量增加至15 mol％，支架的溶解度降低，并且所有这些提取物的pH在30天内从7.0升高到8.5。从支架上累积的离子释放相对于TiO2含量显示出显着差异。以硼酸盐（B2O3）为代价添加5 mol％TiO2显着降低了离子释放。此外，发现对于所有三个支架，累积的离子释放随着孵育时间的增加而增加。结果表明，可以通过改变TiO 2的掺入量来控制硼酸盐生物活性玻璃支架的降解速率和抗压强度，从而证实了它们在TKA和rTKA中作为支架的潜力。

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  • 来源
    《Materials science & engineering》 |2020年第2期|110351.1-110351.11|共11页
  • 作者

    Shafaghi Romina; Rodriguez Omar; Phull Sunjeev; Schemitsch Emil H.; Zalzal Paul; Waldman Stephen D.; Papini Marcello; Towler Mark R.;

  • 作者单位

    Ryerson Univ Dept Biomed Engn Toronto ON M5B 2K3 Canada|St Michael Hosp Li Ka Shing Knowledge Inst Toronto ON M5B 1W8 Canada;

    St Michael Hosp Li Ka Shing Knowledge Inst Toronto ON M5B 1W8 Canada|Ryerson Univ Dept Mech Engn Toronto ON M5B 2K3 Canada;

    St Michael Hosp Li Ka Shing Knowledge Inst Toronto ON M5B 1W8 Canada|Univ Western Ontario Dept Surg London ON N68 4V2 Canada;

    Oakville Trafalgar Mem Hosp Oakville ON L6J 3L7 Canada|McMaster Univ Dept Surg Fac Hlth Sci Hamilton ON L8S 4L8 Canada;

    St Michael Hosp Li Ka Shing Knowledge Inst Toronto ON M5B 1W8 Canada|Ryerson Univ Dept Chem Engn Toronto ON M5B 2K3 Canada;

    Ryerson Univ Dept Biomed Engn Toronto ON M5B 2K3 Canada|Ryerson Univ Dept Mech Engn Toronto ON M5B 2K3 Canada;

    Ryerson Univ Dept Biomed Engn Toronto ON M5B 2K3 Canada|St Michael Hosp Li Ka Shing Knowledge Inst Toronto ON M5B 1W8 Canada|Ryerson Univ Dept Mech Engn Toronto ON M5B 2K3 Canada;

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  • 正文语种 eng
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  • 关键词

    Scaffold; Borate bioactive glass; Titanium; Ion release; Compressive strength;

    机译：脚手架;硼酸盐生物活性玻璃;钛;离子释放;抗压强度;

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