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首页> 外文期刊>Materials science & engineering >Poly(vinyl alcohol)/cationic tannin blend films with antioxidant and antimicrobial activities
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Poly(vinyl alcohol)/cationic tannin blend films with antioxidant and antimicrobial activities

机译：具有抗氧化和抗菌活性的聚乙烯醇/阳离子单宁共混膜

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摘要

This study reports the synthesis, characterization and biological properties of films based on poly(vinyl alcohol) (PVA) and a cationic tannin polymer derivative (TN). Films are obtained from polymeric blends by tuning the PVA/TN weight ratios. The materials are characterized through infrared spectroscopy, X-ray photoelectron spectroscopy, contact angle measurements, mechanical analyses, and scanning electron microscopy. More hydrophilic surfaces are created by modulating the PVA and TN concentrations in the blends. Disintegration tests showed that the films present durability in phosphate buffer (pH 7.4) and low stability in simulated gastric fluid (pH 1.2). The film created at 90/10 PVA/TN weight ratio and crosslinked at 109 PVA/glutaraldehyde molar ratio (sample PVA10/TN10) supports the attachment and proliferation of bone marrow mesenchymal stem cells after 7 days of culture. The scaffolding capacity of the PVA10/TN10 surface is compared with titanium, one of the most important biomedical materials used in bone replacements. Also, the PVA/TN films exhibited cytocompatibility, antioxidant and antimicrobial activity against Staphylococcus aureus and Pseudomonas aeruginosa. These properties make PVA/TN films are candidates for biomedical applications in the tissue engineering field.
机译：这项研究报告了基于聚乙烯醇（PVA）和阳离子单宁聚合物衍生物（TN）的薄膜的合成，表征和生物学特性。通过调节PVA / TN重量比，从聚合物共混物中获得薄膜。通过红外光谱，X射线光电子能谱，接触角测量，机械分析和扫描电子显微镜对材料进行表征。通过调节共混物中的PVA和TN浓度可产生更多的亲水性表面。崩解测试表明，该膜在磷酸盐缓冲液（pH 7.4）中具有耐久性，而在模拟胃液（pH 1.2）中具有较低的稳定性。在培养7天后，以90/10 PVA / TN重量比制成并以109 PVA /戊二醛摩尔比交联的薄膜（样品PVA10 / TN10）支持骨髓间充质干细胞的附着和增殖。将PVA10 / TN10表面的脚手架能力与钛（一种用于骨骼替代的最重要的生物医学材料）进行了比较。此外，PVA / TN膜还表现出针对金黄色葡萄球菌和铜绿假单胞菌的细胞相容性，抗氧化剂和抗菌活性。这些特性使PVA / TN薄膜成为组织工程领域中生物医学应用的候选者。

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