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首页> 外文期刊>Materials science & engineering >Paclitaxel nanocrystalline assemblies as a potential transcatheter arterial chemoembolization (TACE) candidate for unresectable hepatocellular carcinoma
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Paclitaxel nanocrystalline assemblies as a potential transcatheter arterial chemoembolization (TACE) candidate for unresectable hepatocellular carcinoma

机译：紫杉醇纳米晶体组件可作为不可切除肝细胞癌的潜在经导管动脉化疗栓塞（TACE）候选药物

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摘要

We have prepared a water dispersible Nanocrystalline hierarchical structure of paclitaxel using self-assembly approach. Its unique structure provides the advantage of increased payload and higher retention of a chemotherapeutic drug inside the tumor site for a prolonged period. Micron scale structure, sustained release behaviour, multichannel fluorescence property and devoid of any vehicle molecule makes it promising in treating solid tumors through localized drug delivery approach like TACE. This method is based on one pot synthesis through co-precipitation reaction followed by crosslinking. Therapeutic efficacy of the molecules is successfully verified through the significant reduction in the volume of the 3D spheroid model of hepatocellular carcinoma (HCC).
机译：我们使用自组装方法制备了紫杉醇的水分散性纳米晶体分层结构。其独特的结构提供了增加的有效载荷，并延长了化疗药物在肿瘤部位内的保留时间。微米级的结构，持续释放的特性，多通道荧光特性以及不含任何媒介物分子，使其有望通过TACE等局部药物递送方法治疗实体瘤。该方法基于通过共沉淀反应然后交联的一锅法合成。通过大幅减少肝细胞癌（HCC）的3D球形模型的体积，可以成功验证分子的治疗功效。

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