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首页> 外文期刊>Materials science & engineering >Graphene oxide-functionalized long period fiber grating for ultrafast label-free glucose biosensor
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Graphene oxide-functionalized long period fiber grating for ultrafast label-free glucose biosensor

机译：氧化石墨烯功能化的长周期光纤光栅，用于超快的无标记葡萄糖生物传感器

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摘要

A label-free glucose biosensor is constructed successfully based on the long period fiber grating (LPFG) functionalized with graphene oxide (GO)-glucose oxidase (GOD) via the chemical crosslink method. GO coated on the surface of LPFG can immobilize GOD by the plentiful binding sites because of its favorable combination of exceptionally high surface-to-volume ratio. The structure and characterization of GOD-GO-modified LPFG are studied by the optical microscope, Fourier transformation infrared spectrometer (FTIR), Raman spectroscopy, scanning electron microscope (SEM) and atomic force microscopy (AFM), respectively. The reaction between GOD and glucose create gluconic acid and H2O2, which will lead to an evident shift of LPFG transmission spectrum due to the greater change of the surrounding refractive index (SRI). The GOD-GO-modified LPFG sensor shows a linear response with a response coefficient of 0.77 nm/(mg/mL). This biosensor has good selectivity and can be used for the detection of practical sample. The GOD-GO-modified LPFG biosensor has great prospect in the pharmaceutical research and medical diagnosis fields.
机译：基于化学交联法，利用氧化石墨烯（GO）-葡萄糖氧化酶（GOD）功能化的长周期光纤光栅（LPFG），成功构建了无标签葡萄糖生物传感器。 LPFG表面涂覆的GO可以通过大量的结合位点固定GOD，因为它具有极高的表面体积比的有利组合。用光学显微镜，傅立叶变换红外光谱仪（FTIR），拉曼光谱仪，扫描电子显微镜（SEM）和原子力显微镜（AFM）研究了GOD-GO修饰的LPFG的结构和表征。 GOD和葡萄糖之间的反应产生了葡萄糖酸和H2O2，由于周围折射率（SRI）的较大变化，这将导致LPFG透射光谱发生明显变化。经GOD-GO修改的LPFG传感器显示线性响应，响应系数为0.77 nm /（mg / mL）。该生物传感器具有良好的选择性，可用于检测实际样品。经GOD-GO修饰的LPFG生物传感器在药物研究和医学诊断领域具有广阔的前景。

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