Facile synthesis and functionalization of color-tunable Ln~(3+) -doped KGdF_4 nanoparticles on a microfluidic platform

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Facile synthesis and functionalization of color-tunable Ln~(3+) -doped KGdF_4 nanoparticles on a microfluidic platform

机译：Ln〜（3+）掺杂型KGdF_4纳米粒子在微流控平台上的简便合成与功能化

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Hyaluronic acid (HA)-functionalized lanthanide-doped KGdF4 nanoparticles were synthesized through two steps on a microfluidic platform. This microfluidic synthesis method allows better control of experimental conditions with lower labor and energy input than traditional beaker synthesis methods for large-scale production of nanoparticles with higher uniformity. First, Ln(3+)-doped KGdF4 nanoparticles were ultrafast (in minutes) and continuously synthesized using a four-inlets microfluidic chip at room temperature. Then, HA is continuously functionalized on the surface of Ln(3+)-doped KGdF4 nanoparticles using a T-shape chip through electrostatic adsorption. The synthesized nanoparticles show good uniformity, high biocompatibility, targeted cellular uptake, photoluminescence (PL) and magnetic resonance (MR) properties. This work highlights the potential of microfluidic platform for the development of multifunctional nanoparticles in biomedicine.

机译：透明质酸（HA）功能化的镧系元素掺杂的KGdF4纳米颗粒在微流体平台上通过两个步骤合成。与用于大规模生产具有较高均匀度的纳米颗粒的传统烧杯合成方法相比，这种微流体合成方法能够以较低的人工和能量输入更好地控制实验条件。首先，Ln（3+）掺杂的KGdF4纳米颗粒超快（在数分钟内），并在室温下使用四入口微流控芯片连续合成。然后，使用T形芯片通过静电吸附在Ln（3+）掺杂的KGdF4纳米颗粒的表面上将HA连续官能化。合成的纳米颗粒显示出良好的均匀性，高生物相容性，靶向的细胞摄取，光致发光（PL）和磁共振（MR）特性。这项工作突出了微流体平台在生物医学中开发多功能纳米颗粒的潜力。

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《Materials science & engineering》 |2020年第3期|110381.1-110381.8|共8页
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Univ Macau Inst Chinese Med Sci Macau Peoples R China|Sun Yat Sen Univ Sch Biomed Engn Key Lab Sensing Technol & Biomed Instruments Guan Guangzhou 510006 Peoples R China;

Sun Yat Sen Univ Sch Biomed Engn Key Lab Sensing Technol & Biomed Instruments Guan Guangzhou 510006 Peoples R China|Sun Yat Sen Univ Shenzhen Res Inst Shenzhen 518057 Peoples R China;

Univ Macau Inst Chinese Med Sci Macau Peoples R China|Nottingham Trent Univ Sch Sci & Technol Clifton Lane Nottingham NG11 8NS England;

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Ultrafast and continuous synthesis; HA-KGdF4 nanoparticles; Multifunctional; Active tumor targeting; Microfluidic synthesis;

机译：超快连续合成;HA-KGdF4纳米颗粒;多功能;主动肿瘤靶向;微流体合成;

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1. Facile synthesis and functionalization of color-tunable Ln(3+)-doped KGdF4 nanoparticles on a microfluidic platform [J] . Ma Junping, Yi Changqing, Li Cheuk-Wing Materials science & engineering, C. Materials for Biogical applications . 2020,第期

机译：微流体平台上可调谐LN（3 +）掺杂KGDF4纳米粒子的容易合成及官能化
2. Facile synthesis and color-tunable properties of monodisperse beta-NaYF4:Ln(3+) (Ln = Eu, Tb, Tm, Sm, Ho) microtubes [J] . Yang Junfeng, Song Lina, Wang Xiaoxue, Dalton transactions: An international journal of inorganic chemistry . 2018,第4期

机译：单分散性β-Nayf4：Ln（3+）（LN = Eu，Tb，Tm，Sm，Ho）微管的容易合成和可显色性能
3. Facile Synthesis of Multifunctional β-NaGdF_4:Yb~(3+)/Er~(3+) Nanoparticles in Oleylamine [J] . Qian Cheng, Jiehe Sui, Yu Li, Journal of nanoscience and nanotechnology . 2013,第1期

机译：在油胺中轻松合成多功能β-NaGdF_4：Yb〜（3 +）/ Er〜（3+）纳米粒子
4. Silica coated, aminosilane functionalization, upconversion emission and cytotoxicity in cancer cell lines of the nanoparticles Y_2O_3 and Gd_2O_3 co-doped with Yb~(3+) and Er~(3+) [C] . D. Chavez, K. Juarez-Moreno, G. A. Hirata International Materials Research Congress . 2016

机译：二氧化硅涂覆，氨基硅烷官能化，纳米颗粒的癌细胞系中的升级发射和细胞毒性Y_2O_3和GD_2O_3与YB〜（3+）和ER〜（3+）共掺杂
5. Design, synthesis and characterization of functionalized SCK nanoparticles and functionalized biocompatible surfaces: Construction platforms for nanoparticle assembly and biomacromolecule immobilization. [D] . Qi, Kai. 2005

机译：功能化SCK纳米颗粒和功能化生物相容性表面的设计，合成和表征：纳米粒子组装和生物大分子固定化的构建平台。
6. Facile High Throughput Wet-Chemical Synthesis Approach Using a Microfluidic-Based Composition and Temperature Controlling Platform [O] . Yang Hu, Bin Liu, Yating Wu, 2020

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7. Facile synthesis of PdO-doped Co3O4 nanoparticles as an efficient bifunctional oxygen electrocatalyst [O] . Tianjun Hu, Ying Wang, Lina Zhang, 2019

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Facile synthesis and functionalization of color-tunable Ln~(3+) -doped KGdF_4 nanoparticles on a microfluidic platform

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