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首页> 外文期刊>Materials science & engineering >Advances in cartilage repair: The influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels
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Advances in cartilage repair: The influence of inorganic clays to improve mechanical and healing properties of antibacterial Gellan gum-Manuka honey hydrogels

机译：软骨修复的进展：无机粘土对抗菌结冷胶-Manuka蜂蜜水凝胶的机械和愈合特性的影响

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摘要

Effective treatment of cartilage defects represents a challenging problem, mainly due to the tissue's limited intrinsic self-repair capacity; the use of polymeric scaffolds as tissue substitute is rapidly increasing, but it is still limited by poor mechanical properties. Moreover, the onset of an infection can irreversibly affect the healing process. Accordingly, in this work we describe, for the first time, the preparation of composite scaffolds based on gellan gum, antibacterial Manuka honey and an inorganic clay (mesoporous silica, sodium-calcium bentonite or halloysite nanotubes). The surface composition, morphology, mechanical and biological features of such composites are herein assessed, aiming to optimize the composition of a superior scaffold for cartilage repair. Results demonstrated that after 45 days of in vitro incubation with human mesenchymal stem cells, the mesoporous silica-composite hydrogels exhibited significant changes in peak elastic and dynamic moduli over time thus demonstrating superior mechanical properties. Moreover, mesoporous silica provided the best performances in terms of in vitro cytocompatibility and antibacterial preventive activity in protection of cells in a co-culture model. Therefore, this selected composition was exploited for subcutaneous implantation in mice to investigate materials biocompatibility and infection prevention. Results demonstrated that composites did not cause severe immune response as well as they were able to restrain the infection. Accordingly, GG-MH-MS composites represent a very promising tool for cartilage tissue engineering.
机译：有效治疗软骨缺损是一个具有挑战性的问题，这主要是由于组织内在的自我修复能力有限。聚合物支架作为组织替代物的使用正在迅速增加，但是仍然受到不良机械性能的限制。而且，感染的发作可以不可逆地影响愈合过程。因此，在这项工作中，我们首次描述了基于结冷胶，抗菌麦卢卡蜂蜜和无机粘土（介孔二氧化硅，钠钙膨润土或埃洛石纳米管）的复合支架的制备。本文评估了此类复合材料的表面组成，形态，机械和生物学特征，旨在优化用于软骨修复的优质支架的组成。结果表明，在与人间充质干细胞体外温育45天后，介孔二氧化硅复合水凝胶随时间显示出峰值弹性和动态模量的显着变化，从而证明了优异的机械性能。此外，在共培养模型中，在体外细胞相容性和抗菌保护活性方面，介孔二氧化硅提供了最佳性能。因此，将这种选择的组合物用于小鼠皮下植入，以研究材料的生物相容性和预防感染。结果表明，复合材料不会引起严重的免疫反应，并且能够抑制感染。因此，GG-MH-MS复合材料代表了一种非常有前途的软骨组织工程工具。

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  • 来源
    《Materials science & engineering》 |2020年第3期|110444.1-110444.12|共12页
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    Univ Bari Aldo Moro Dept Chem Via E Orabona 4 I-70126 Bari Italy;

    Univ Piemonte Orientale UPO Dept Hlth Sci Ctr Translat Res Autoimmune & Allergic Dis CAAD C So Trieste 15-A I-28100 Novara Italy;

    Jaber Innovat Srl Via Calcutta 8 I-00144 Rome Italy;

    Newcastle Univ Sch Engn Stephenson Bldg Claremont Rd Newcastle Upon Tyne NE1 7RU Tyne & Wear England;

    Univ Bari Aldo Moro Dept Biosci Biotechnol & Biopharmaceut Via E Orabona 4 I-70126 Bari Italy;

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  • 正文语种 eng
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  • 关键词

    Composite hydrogels; Gellan gum; Inorganic clays; Antibacterial; Cytocompatibility; Cartilage repair;

    机译：复合水凝胶;结冷胶无机粘土;抗菌;细胞相容性;软骨修复;

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