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首页> 外文期刊>Materials science & engineering >Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold
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Surface modification enhances interfacial bonding in PLLA/MgO bone scaffold

机译：表面改性可增强PLLA / MgO骨支架中的界面结合

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摘要

The poor interfacial bonding and resultant agglomeration of nanoparticles in polymer-based composite severely deteriorated their reinforcement effect. In this work, MgO nanoparticles (MgO-NPs) were surface modified with Poly (L-lactic acid-co-malic acid) (PLMA) to improve the interfacial compatibility in Poly-l-lactic acid (PLLA) scaffold manufactured by selective laser sintering. PLMA possess a hydrophilic end with carboxyl group (comes from the malic acid) and an I-lactic acid chain. On one hand, the carboxyl group was able to form hydrogen bonding with the hydroxyl groups of MgO-NPs. On the other hand, the l-lactic acid chain containing the hydroxyl groups could react with the carboxyl group of PLLA. Results revealed that the scaffold exhibited significantly enhanced compressive strength and modulus by 47.1% and 237.7%, respectively, which could be ascribed to the enhanced interfacial bonding between PLLA and MgO-NPs, as well as the rigid particle reinforcement. In addition, the scaffold was favorable for cell adhesion, proliferation and differentiation, owing to the improved hydrophilic and suitable pH environment. It was suggested the scaffold was a promising material for bone repair application.
机译：聚合物基复合材料中不良的界面键合和纳米颗粒的团聚严重恶化了其增强效果。在这项工作中，MgO纳米颗粒（MgO-NPs）用聚（L-乳酸-苹果酸）（PLMA）进行了表面改性，以改善通过选择性激光制造的聚1-乳酸（PLLA）支架的界面相容性烧结。 PLMA的亲水端带有羧基（来自苹果酸）和I-乳酸链。一方面，羧基能够与MgO-NPs的羟基形成氢键。另一方面，含有羟基的1-乳酸链可与PLLA的羧基反应。结果显示，支架的抗压强度和模量分别显着提高了47.1％和237.7％，这可以归因于PLLA和MgO-NP之间的界面键增强以及刚性颗粒增强。另外，由于改善的亲水性和合适的pH环境，该支架有利于细胞粘附，增殖和分化。提示该支架是用于骨修复应用的有前途的材料。

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  • 来源
    《Materials science & engineering》 |2020年第3期|110486.1-110486.10|共10页
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  • 作者单位

    Jiangxi Univ Sci & Technol Ganzhou 341000 Peoples R China|Cent S Univ State Key Lab High Performance Complex Mfg Changsha 410083 Peoples R China;

    Jiangxi Univ Sci & Technol Ganzhou 341000 Peoples R China;

    Cent S Univ Xiangya Hosp NHC Key Lab Carcinogenesis Changsha Hunan Peoples R China|Cent S Univ Sch Basic Med Sci Canc Res Inst Changsha Hunan Peoples R China|Cent S Univ Xiangya Hosp Key Lab Carcinogenesis & Canc Invas Chinese Minist Educ Changsha Hunan Peoples R China;

    Nanjing Univ Aeronaut & Astronaut Coll Mech & Elect Engn Nanjing 210016 Peoples R China;

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  • 正文语种 eng
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  • 关键词

    Surface modification; PLLA scaffold; Interfacial bonding; Mechanical properties; Degradation behavior;

    机译：表面改性;PLLA脚手架;界面结合;机械性能降解行为;

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