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首页> 外文期刊>Materials science & engineering >Fabrication of flexible composite drug films via foldable linkages using electrohydrodynamic printing
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Fabrication of flexible composite drug films via foldable linkages using electrohydrodynamic printing

机译：使用电动流体动力印刷通过可折叠的连接制备柔性复合药物薄膜

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摘要

The simple method to manufacture a flexible multi-drug with hydrophilic and hydrophobic molecules-loaded composite membrane via three dimensional (3D) electrohydrodynamic (EHD) printing has been demonstrated in this study. The composite membrane consists of two different drug-loaded sections: cellulose acetate-ibuprofen (CA-IBU) and cellulose acetate-paracetamol (CA-Para), respectively, with an intermediate polycaprolactone (PCL) folding component. The composite membranes can be folded and housed in commercial capsules to aid swallowing. By changing the number of PCL layers in the intermediate layers, it is possible to control and modify the mechanical and unfolding properties of the composite membrane. IBU and Para are loaded into the CA polymeric matrix in their amorphous states, with the matrices exhibiting Higuchi and first order release kinetics, respectively. The combination of IBU and Para can potentially be used as analgesic for patients. Magnetic nanoparticles as a functional material can be incorporated into the PCL matrix for wide targeting and traceable applications. The composite membrane here possesses good biocompatibility and flexibility; enabling extensive application prospects in drug combination therapy and personalized medicine.
机译：这项研究证明了通过三维（3D）电流体动力学（EHD）印刷来制造带有亲水性和疏水性分子复合膜的柔性多药的简单方法。复合膜由两个不同的载药部分组成：醋酸纤维素-布洛芬（CA-IBU）和醋酸纤维素-对乙酰氨基酚（CA-Para），中间有聚己内酯（PCL）折叠成分。可以将复合膜折叠并容纳在商用胶囊中以帮助吞咽。通过改变中间层中PCL层的数量，可以控制和改变复合膜的机械性能和展开性能。 IBU和Para以其非晶态被加载到CA聚合物基质中，基质分别表现出Higuchi和一级释放动力学。 IBU和Para的组合可潜在地用作患者的镇痛药。可以将磁性纳米颗粒作为功能材料掺入PCL基质中，以实现广泛的靶向和可追溯的应用。这里的复合膜具有良好的生物相容性和柔韧性。在药物联合疗法和个性化药物方面具有广阔的应用前景。

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  • 来源
    《Materials science & engineering》 |2020年第3期|110393.1-110393.9|共9页
  • 作者

  • 作者单位

    Zhejiang Univ Minist Educ Key Lab Dept Biomed Engn Hangzhou 310027 Peoples R China|Zhejiang Univ Zhejiang Prov Key Lab Cardiocerebral Vasc Detect Hangzhou 310027 Peoples R China;

    De Montfort Univ Leicester Sch Pharm Leicester LE1 9BH Leics England;

    Zhejiang Univ Minist Educ Key Lab Dept Biomed Engn Hangzhou 310027 Peoples R China;

    Zhejiang Univ Minist Educ Key Lab Dept Biomed Engn Hangzhou 310027 Peoples R China|Zhejiang Univ Zhejiang Prov Key Lab Cardiocerebral Vasc Detect Hangzhou 310027 Peoples R China|Univ Ulster Nanotechnol & Integrated Bioengn Ctr Jordanstown Campus Newtownabbey BT37 0QB North Ireland;

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  • 正文语种 eng
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  • 关键词

    3D printing; Folding; Drug delivery; Composite;

    机译：3D打印折叠药物输送;综合;

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