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首页> 外文期刊>Materials science & engineering >Polymethyl methacrylate (PMMA) grafted collagen scaffold reinforced by PdO-TiO_2 nanocomposites
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Polymethyl methacrylate (PMMA) grafted collagen scaffold reinforced by PdO-TiO_2 nanocomposites

机译：PdO-TiO_2纳米复合材料增强的聚甲基丙烯酸甲酯（PMMA）接枝胶原蛋白支架

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In the past few decades, the design and fabrication of bio-scaffolds exhibiting structural stability In long-term and biocompatibility has received much attention in the field of tissue engineering application. In this direction, we have synthesized different mole ratio of PdO-TiO2 nanocomposites (1:1, 2:1 and 3:1 of Pd:Ti, size 5-11nm, 7-16 nm and 9-22 nm) through a simple single step sol gel method. The obtained nanocomposites of different sizes were assimilated into poly (methyl methacrylate) grafted collagen biopolymer (g-PMMA-Collagen), resulting in a PdO-TiO2-g-PMMA-Collagen based scaffold. Physico-chemical properties and biocompatibility of g-PMMA-Collagen/PdO TiO2-g-PMMA-Collagen scaffolds were analysed by using various techniques such as XRD, FT-IR, TGA, DSC, Universal Testing Machine, MTT, Alkaline phosphatase, Alizarin Red S staining assay and the obtained results were compared against pure collagen scaffold. Our results suggest that the incorporation of 1:1 mol ratio PdO-TiO2 nanocomposite (Size, 5-11 nm) offers a higher thermal stability (83.45 degrees C) and mechanical strength (Young's modulus 105.57 MPa) than the pure collagen scaffold (71.64 degrees C, 11.67 MPa). The PdO-TiO2 endowed scaffolds were not toxic to MG 63 cells (human osteosarcoma) and enhanced the ALP activity on the scaffolds during in vitro osteogenic differentiation. This work provides a new approach for mechanical reinforcing and enhanced osteogenic activity of collagen scaffolds without affecting its conformation or biocompatibility, an aspect that possibly makes them ideal for bone tissue engineering applications.
机译：在过去的几十年中，显示出长期结构稳定性的生物支架的设计和制造和生物相容性在组织工程应用领域受到了广泛的关注。在这个方向上，我们通过简单的方法合成了不同摩尔比的PdO-TiO2纳米复合材料（Pd：Ti的1：1、2：1和3：1，尺寸为5-11nm，7-16 nm和9-22 nm）。单步溶胶凝胶法。将获得的不同尺寸的纳米复合材料同化到聚（甲基丙烯酸甲酯）接枝的胶原生物聚合物（g-PMMA-胶原蛋白）中，从而得到基于PdO-TiO2-g-PMMA-胶原蛋白的支架。使用XRD，FT-IR，TGA，DSC，Universal Testing Machine，MTT，碱性磷酸酶，茜素等多种技术分析了g-PMMA-胶原/ PdO TiO2-g-PMMA-胶原支架的理化性质和生物相容性将Red S染色法和获得的结果与纯胶原蛋白支架进行比较。我们的结果表明，掺入1：1摩尔比的PdO-TiO2纳米复合材料（尺寸，5-11 nm）比纯胶原蛋白支架（71.64）具有更高的热稳定性（83.45摄氏度）和机械强度（杨氏模量105.57 MPa）。 C，11.67 MPa）。赋予PdO-TiO2的支架对MG 63细胞（人骨肉瘤）无毒，并在体外成骨分化过程中增强了支架上的ALP活性。这项工作提供了一种机械增强和增强胶原蛋白支架的成骨活性而不影响其构象或生物相容性的新方法，这一方面可能使它们成为骨组织工程应用的理想选择。

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