...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials science & engineering >Fabrication of electroactive polypyrrole-tungsten disulfide nanocomposite for enhanced in vivo drug release in mice skin
【24h】

Fabrication of electroactive polypyrrole-tungsten disulfide nanocomposite for enhanced in vivo drug release in mice skin

机译：电活性聚吡咯-钨二硫化物纳米复合材料的制备增强了小鼠皮肤的体内药物释放

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The present study focused on the development of electric stimuli drug release carrier based on transition metal dicgalcogenides. First, tungsten disulfide (WS2) was exfoliated and functionalized using thiol chemistry with various thiol-terminated ligands such as thioglycolic acid (TGA), mercaptosuccinic acid (MSA), and 2-ethanethiol (2ET). The exfoliated WS2 underwent non-covalent coating with an electrically conductive polypyrrole (PPy) for functionalization, of which MSA-WS2-PPy achieved the highest 5-FU (anticancer drug) loading. An electrically-stimulated drug release experiment showed that TGA-WS2-PPy achieved a higher drug release (90%) than MSA-WS2-PPy (70%) and 2ET-WS2-PpY (35%). The TGA-WS2-PPy exhibited swelling/recombination between PPY and MSA-WS2 substrate under electrical stimulation, resulting in the highest 5-FU release. From the MTT assay result, there was no significant toxicity observed for TGA-WS2-PPy-FU on HaCaT cells, indicating the biocompatibility of TGA-WS2-PPy-FU in the absence of electrical stimulation. However, HaCaT cells died when incubated with TGA-WS2-PPy-FU under electrical stimulation. Finally, Raman mapping studies for TGA-WS2-PPy drug release in the skin of nude mice demonstrated that the carrier penetrated deeper into the skin of the mice while other systems failed to exhibit significant effects under electrical stimulation. The present study offers a novel approach in developing a non-invasive electrically-stimulated drug release system based on WS2 and an externally-controlled delivery model.
机译：本研究的重点是基于过渡金属双氰胺的电刺激药物释放载体的开发。首先，使用具有各种巯基封端的配体（例如巯基乙酸（TGA），巯基琥珀酸（MSA）和2-乙硫醇（2ET））的硫醇化学对二硫化钨（WS2）进行剥离和功能化。剥落的WS2进行了非共价涂层，并使用了导电的聚吡咯（PPy）进行功能化，其中MSA-WS2-PPy获得了最高的5-FU（抗癌药物）负载。电刺激药物释放实验表明，TGA-WS2-PPy的药物释放率（90％）高于MSA-WS2-PPy（70％）和2ET-WS2-PpY（35％）。在电刺激下，TGA-WS2-PPy在PPY和MSA-WS2底物之间表现出溶胀/重组，导致最高的5-FU释放。从MTT测定结果来看，在HaCaT细胞上没有观察到TGA-WS2-PPy-FU的明显毒性，表明在没有电刺激的情况下TGA-WS2-PPy-FU的生物相容性。但是，在电刺激下与TGA-WS2-PPy-FU孵育后，HaCaT细胞死亡。最后，对裸鼠皮肤中TGA-WS2-PPy药物释放的拉曼作图研究表明，载体在小鼠的皮肤中更深地渗透，而其他系统在电刺激下却没有表现出明显的作用。本研究为开发基于WS2和外部控制的传递模型的无创电刺激药物释放系统提供了一种新颖的方法。

著录项

  • 来源
    《Materials science & engineering》 |2020年第2期|110330.1-110330.10|共10页
  • 作者

  • 作者单位

    Mackay Mem Hosp Dept Dermatol Taipei Taiwan|Nursing & Management Coll Mackay Med Taipei Taiwan|Mackay Med Coll New Taipei Taiwan;

    Natl Taiwan Univ Sci & Technol Grad Inst Appl Sci & Technol Taipei Taiwan|Natl Taiwan Univ Sci & Technol Grad Inst Appl Sci & Technol Adv Membrane Mat Res Ctr Taipei Taiwan;

    Natl Taiwan Univ Sci & Technol Grad Inst Appl Sci & Technol Taipei Taiwan;

    Ind Technol Res Inst Hsinchu Taiwan;

    Natl Taiwan Univ Sci & Technol Grad Inst Electroopt Engn Taipei Taiwan|Natl Taiwan Univ Sci & Technol Dept Elect & Comp Engn Taipei Taiwan;

    Natl Taiwan Univ Sci & Technol Dept Biomed Engn Taipei Taiwan;

    Natl Taiwan Univ Sci & Technol Grad Inst Appl Sci & Technol Taipei Taiwan|Natl Taiwan Univ Sci & Technol Grad Inst Appl Sci & Technol Adv Membrane Mat Res Ctr Taipei Taiwan|Chung Yuan Christian Univ R&D Ctr Membrane Technol Chungli Taiwan|Chung Yuan Christian Univ Dept Chem Engn Chungli Taiwan;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Tungsten disulfide (WS2); Exfoliation; Polypyrrole (PPy); Conducting polymer; Electrical property; In vivo drug release;

    机译：二硫化钨（WS2）;去角质聚吡咯（PPy）;导电聚合物;电气性能;体内药物释放;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号