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首页> 外文期刊>Materials science & engineering >Study on strontium doped tricalcium silicate synthesized through sol-gel process
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Study on strontium doped tricalcium silicate synthesized through sol-gel process

机译：溶胶-凝胶法合成锶掺杂硅酸三钙的研究

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摘要

We successfully synthesized a strontium-doped tricalcium silicate (SrxCa3-xSiO5, Sr = 0 to 2 mol%) bone cement using the sol-gel process. The material properties including crystallinity, setting time, mechanical strength, and hydration products were characterized. Release of ions and pH values of simulated body fluid soaked with the bone cement were measured. In vitro biocompatibility of different concentrations of the material was evaluated by the viability of L929 cells. The setting times of as-prepared slurries were all <70 min. Doping with 0.5 mol% Sr reduced the final setting time by 20 min. After 14 days curing, 0.25 mol% Sr-doped SrxCa3-xSiO5 possessed the highest compressive strength of 45 MPa among all the Sr-doped groups with no statistical difference to Ca3SiO5. The bioactivity of the materials was confirmed with the formation of an apatite layer on the surface of the materials after immersion in simulated body fluid. In addition, the proliferation of L929 cells exposed to 1 mol% Sr was significantly promoted as compared to no Sr doping. SrxCa3-xSiO5 is a novel and advanced material that has the potential to serve as a bone cement in bone restoration with appropriate mechanical strength and favorable biocompatibility.
机译：我们使用溶胶-凝胶法成功合成了锶掺杂硅酸三钙（SrxCa3-xSiO5，Sr = 0至2 mol％）骨水泥。表征了包括结晶度，凝固时间，机械强度和水合产物在内的材料性能。测量用骨水泥浸泡的模拟体液的离子释放和pH值。通过L929细胞的活力评估了不同浓度材料的体外生物相容性。所制备的浆料的凝固时间均＜70分钟。掺杂0.5 mol％Sr可将最终凝固时间减少20分钟。固化14天后，在所有Sr掺杂基团中0.25 mol％的Sr掺杂SrxCa3-xSiO5具有最高的抗压强度，为45 MPa，与Ca3SiO5没有统计学差异。浸入模拟体液后，通过在材料表面形成磷灰石层来确认材料的生物活性。另外，与未掺杂Sr相比，暴露于1mol％Sr的L929细胞的增殖被显着促进。 SrxCa3-xSiO5是一种新型的先进材料，具有以适当的机械强度和良好的生物相容性在骨修复中用作骨水泥的潜力。

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  • 来源
    《Materials science & engineering》 |2020年第3期|110431.1-110431.7|共7页
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    Natl Taipei Univ Technol Taipei Tech Dept Chem Engn & Biotechnol Taipei 106 Taiwan;

    Chang Gung Mem Hosp Bone & Joint Res Ctr Linkou Taiwan|Chang Gung Mem Hosp Dept Orthopaed Surg Linkou Taiwan|Chang Gung Univ Coll Med Taoyuan Taiwan;

    Taipei Med Univ Shuang Ho Hosp Dept Surg Div Neurosurg New Taipei Taiwan|Taipei Med Univ Coll Med Sch Med Dept Surg Taipei 11031 Taiwan;

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  • 正文语种 eng
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  • 关键词

    Tricalcium silicate; Strontium; Sol-gel process; Bone cement; Biocompatibility;

    机译：硅酸三钙;锶;溶胶-凝胶法;骨水泥;生物相容性;

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