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首页> 外文期刊>Materials science & engineering >Investigation on Au-nano incorporated pH-sensitive (itaconic acid/ acrylic acid/triethylene glycol) based polymeric biocompatible hydrogels
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Investigation on Au-nano incorporated pH-sensitive (itaconic acid/ acrylic acid/triethylene glycol) based polymeric biocompatible hydrogels

机译：基于金纳米的pH敏感型（衣康酸/丙烯酸/三乙二醇）聚合物生物相容性水凝胶的研究

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摘要

The pH-sensitive gold nano hydrogel based on itaconic acid, acrylic acid and triethylene glycol (GIAT) has been prepared by free radical polymerization viz organic solventless approach with different monomer ratios. The na¬ ture of bonding and structural identification of GIAT hydrogels were characterized by FT-IR spectroscopy. The surface morphology of gold gel was examined using scanning electron microscopy (SEM). In addition, transmis¬ sion electron microscopy (TEM) was used to identify the size of gold nano particles. The in vitro biocompatibility of GIAT hydrogel has been evaluated in 3T3 fibroblast cell lines. The obtained results show that gold nano particle incorporated hydrogel possess -99% of cell proliferation. Followed by, the impact of gold nano particles on swell¬ ing, surface morphology was studied. The consecutive preparation of hydrogel, effect of different pH conditions, and stoichiometry of monomeric units have also been discussed. The degree of swelling was measured in carbon¬ ate buffer solutions for 24 h period with varying pH such as 12,6.0,7.4 and 10.0. The obtained results showed that the stoichiometry of itaconic acid and gold nano particles plays an essential role in modifying the nature of GIAT polymeric hydrogels. In conclusion, promising Au-nano incorporated pH-sensitive bio polymeric hydrogels were prepared and characterized. The unique properties of these Au-nano hydrogel make them attrac¬ tive use in biomedical applications.
机译：基于衣康酸，丙烯酸和三甘醇（GIAT）的pH敏感型金纳米水凝胶是通过自由基聚合反应通过无单体比例的有机无溶剂方法制备的。通过FT-IR光谱表征了GIAT水凝胶的键合性质和结构鉴定。使用扫描电子显微镜（SEM）检查了金凝胶的表面形态。另外，使用透射电子显微镜（TEM）鉴定金纳米颗粒的尺寸。 GIAT水凝胶的体外生物相容性已在3T3成纤维细胞系中进行了评估。获得的结果表明，掺有金纳米颗粒的水凝胶具有-99％的细胞增殖。随后，研究了金纳米颗粒对溶胀，表面形态的影响。还讨论了水凝胶的连续制备，不同pH条件的影响以及单体单元的化学计量。在碳酸盐缓冲溶液中在24小时内测量pH值（例如12、6.0、7.4和10.0）变化的溶胀度。所得结果表明衣康酸和金纳米颗粒的化学计量在改变GIAT聚合物水凝胶的性质中起着至关重要的作用。总之，制备并表征了有前途的掺有金纳米的pH敏感生物聚合物水凝胶。这些金纳米水凝胶的独特性质使其在生物医学应用中具有吸引力。

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  • 来源
    《Materials science & engineering》 |2017年第6期|517-523|共7页
  • 作者

    M. Sakthivel; D.S. Franklin; S. Sudarsan; G. Chitra; S. Guhanathan;

  • 作者单位

    Research and Development Centre, Bharathiar University, Coimbatore 641 046, Tamilnadu, India,Department of Chemistry, Ganadipathy Tulsi's Jain Engineering College, Kaniyambadi, Vellore 632 102, Tamilnadu, India;

    Department of Chemistry, C. Abdul Hakeem College of Engineering and Technology, Melvisharam 632509, Tamilnadu, India;

    Department of Chemistry, Periyar University, Salem 636011, Tamilnadu, India;

    Department of Chemistry, Periyar University, Salem 636011, Tamilnadu, India;

    PG & Research Department of Chemistry, Muthurangam Government Arts College, Vellore632 002, Tamilnadu, India;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Itaconic acid; Acrylic acid; pH-sensitive hydrogels; Swelling; Biocompatible;

    机译：衣康酸;丙烯酸;pH敏感水凝胶;肿胀;生物相容性;

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