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首页> 外文期刊>Materials science & engineering >Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application
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Tailoring the degradation and biological response of a magnesium-strontium alloy for potential bone substitute application

机译：量身定制镁-锶合金的降解和生物响应，以用于潜在的骨替代应用

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摘要

Bone defects are very challenging in orthopedic practice. There are many practical and clinical shortcomings in the repair of the defect by using autografts, allografts or xenografts, which continue to motivate the search for better alternatives. The ideal bone grafts should provide mechanical support, fill osseous voids and enhance the bone healing. Biodegradable magnesium-strontium (Mg-Sr) alloys demonstrate good biocompatibility and osteoconductive properties, which are promising biomaterials for bone substitutes. The aim of this study was to evaluate and pair the degradation of Mg-Sr alloys for grafting with their clinical demands. The microstruc-ture and performance of Mg-Sr alloys, in vitro degradation and biological properties including in vitro cytocompatibility and in vivo implantation were investigated. The results showed that the as-cast Mg-Sr alloy exhibited a rapid degradation rate compared with the as-extruded alloy due to the intergranular distribution of the second phase and micro-galvanic corrosion. However, the initial degradation could be tailored by the coating protection, which was proved to be cytocompatible and also suitable for bone repair observed by in vivo implantation. The integrated fracture calluses were formed and bridged the fracture gap without gas bubble accumulation, meanwhile the substitutes simultaneously degraded. In conclusion, the as-cast Mg-Sr alloy with coating is potential to be used for bone substitute alternative.
机译：骨缺损在整形外科中非常具有挑战性。通过使用自体移植物，同种异体移植物或异种移植物修复缺损有许多实际和临床缺陷，这继续促使人们寻找更好的替代物。理想的骨移植物应提供机械支撑，填充骨性空隙并增强骨愈合。可生物降解的镁锶（Mg-Sr）合金具有良好的生物相容性和骨传导性能，是有望替代骨骼的生物材料。这项研究的目的是评估和嫁接Mg-Sr合金的降解及其临床需求。研究了Mg-Sr合金的微观结构和性能，体外降解和生物学特性，包括体外细胞相容性和体内植入。结果表明，由于第二相的晶间分布和微电偶腐蚀，铸态的Mg-Sr合金与挤压态的合金相比，降解速度快。然而，最初的降解可以通过涂层保护来定制，该涂层保护被证明具有细胞相容性，并且还适合通过体内植入观察到的骨修复。形成了完整的裂缝愈伤组织并弥合了裂缝缝隙，没有气泡积聚，同时替代物同时降解。总而言之，具有涂层的铸态Mg-Sr合金有望用于替代骨替代品。

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  • 来源
    《Materials science & engineering》 |2016年第1期|799-811|共13页
  • 作者

    Junjie Han; Peng Wan; Ye Ge; Xinmin Fan; Lili Tan; Jianjun Li; Ke Yang;

  • 作者单位

    Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China,Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China;

    Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China;

    Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 100004, China;

    Department of Materials Science and Engineering, Nanjing University of Science and Technology, Nanjing 210094, China;

    Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China;

    Shengjing Hospital of China Medical University, 36 Sanhao Street, Shenyang 100004, China;

    Institute of Metal Research, Chinese Academy of Sciences, 72 Wenhua Road, Shenyang 110016, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bone substitutes; Magnesium alloys; Strontium; Degradation; In vivo;

    机译：骨替代物;镁合金;锶;降解;体内;

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