Radiation damage on Langmuir monolayers of the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt)(DPPG) phospholipid at the air-DNA solution interface

Paulo J. Gomes; Amelia M.P.S. Goncalves da Silva; Paulo A. Ribeiro; Osvaldo N. Oliveira Jr; Maria Raposo

首页> 外文期刊>Materials science & engineering >Radiation damage on Langmuir monolayers of the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt)(DPPG) phospholipid at the air-DNA solution interface

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Radiation damage on Langmuir monolayers of the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt)(DPPG) phospholipid at the air-DNA solution interface

机译：空气-DNA溶液界面上阴离子1.2-二棕榈酰基-sn-甘油-3- [磷酸-rac-（1-甘油）]（钠盐）（DPPG）磷脂对Langmuir单层的辐射损伤

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The resilience of cells to ultraviolet (UV) irradiation is probably associated with the effects induced in biological molecules such as DNA and in the cell membrane. In this study, we investigated UV damage to the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt) (DPPG) phospholipid, which is an important component of cell membranes. In films cast from DPPG emulsions, UV irradiation induced cleavage of C-O, C = O and -PO~(2-) bonds, while in Langmuir monolayers at the air/water interface representing the cell membrane this irradiation caused the monolayer stability to decrease. When DNA was present in the subphase, however, the effects from UV irradiation were smaller, since the ionic products from degradation of either DPPG or DNA stabilize the intact DPPG molecules. This mechanism may explain why UV irradiation does not cause immediate cell collapse, thus providing time for the cellular machinery to repair elements damaged by UV.

机译：细胞对紫外线（UV）的恢复能力可能与在生物分子（例如DNA）和细胞膜中诱导的效应有关。在这项研究中，我们调查了紫外线对阴离子1.2-二棕榈酰基-sn-甘油-3- [磷酸-rac-（1-甘油）]（钠盐）（DPPG）磷脂的损害，磷脂是细胞膜的重要组成部分。在由DPPG乳液流延而成的薄膜中，紫外线辐射引起C-O，C = O和-PO〜（2-）键的裂解，而在代表细胞膜的空气/水界面的Langmuir单层中，这种辐照导致单层稳定性降低。但是，当亚相中存在DNA时，由于DPPG或DNA降解产生的离子产物稳定了完整的DPPG分子，因此紫外线照射的影响较小。这种机制可以解释为什么紫外线辐射不会立即导致细胞崩溃，从而为细胞机械提供了时间来修复被紫外线破坏的元素。

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来源
《Materials science & engineering》 |2016年第1期|576-579|共4页
作者
Paulo J. Gomes; Amelia M.P.S. Goncalves da Silva; Paulo A. Ribeiro; Osvaldo N. Oliveira Jr; Maria Raposo;
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作者单位

CEFITEC, Departamento de Fisica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal;

Centro de Quimica Estrutural, Complexo Ⅰ, Instituto Superior Tecnico, Universidade de Lisboa, Av Rovisco Pais, 1049-001 Lisboa, Portugal;

CEFITEC, Departamento de Fisica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal;

Instituto de Fisica de Sao Carlos, Universidade de Sao Paulo, CP 369, 13560-970 Sao Carlos, Sao Paulo, Brazil;

CEFITEC, Departamento de Fisica, Faculdade de Ciencias e Tecnologia, Universidade Nova de Lisboa, 2829-516 Caparica, Portugal;

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正文语种 eng
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关键词
DNA; DPPG; Langmuir films; UV radiation; Radiation damage;

机译：脱氧核糖核酸;DPPG;朗缪尔电影;紫外线辐射;辐射损伤;

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1. Radiation damage on Langmuir monolayers of the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt) (DPPG) phospholipid at the air-DNA solution interface [J] . Gomes Paulo J., da Silva Amelia M. P. S. Goncalves, Ribeiro Paulo A., Materials science & engineering, C. Materials for Biogical applications . 2016,第Null期

机译：空气-DNA溶液界面上阴离子1.2-二棕榈酰基-sn-甘油-3- [磷酸-rac-（1-甘油）]（钠盐）（DPPG）磷脂对Langmuir单层的辐射损伤
2. Langmuir monolayer studies of the interaction of monoamphiphilic pentacyclic triterpenes with anionic mitochondrial and bacterial membrane phospholipids - Searching for the most active terpene [J] . BroniatowskiM., FlasińskiM., Zi?baK., Biochimica et biophysica acta. Biomembranes . 2014,第10期

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Radiation damage on Langmuir monolayers of the anionic 1.2-dipalmitoyl-sn-glycero-3-[phospho-rac-(1-glycerol)] (sodium salt)(DPPG) phospholipid at the air-DNA solution interface

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