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首页> 外文期刊>Materials science & engineering >Stimuli-responsive weak polyelectrolyte multilayer films: A thin film platform for self triggered multi-drug delivery
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Stimuli-responsive weak polyelectrolyte multilayer films: A thin film platform for self triggered multi-drug delivery

机译：刺激敏感的弱聚电解质多层膜：用于自触发多药递送的薄膜平台

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摘要

Polyelectrolyte multilayer (PEM) thin film composed of weak polyelectrolytes was designed by layer-by-layer (LbL) assembly of poly(allylamine hydrochloride) (PAH) and poly(methacrylic acid) (PMA) for multi-drug delivery applications. Environmental stimuli such as pH and ionic strength showed significant influence in changing the film morphology from pore-free smooth structure to porous structure and favored triggered release of loaded molecules. The film was successfully loaded with bovine serum albumin (BSA) and ciprofloxacin hydrochloride (CH) by modulating the porous polymeric network of the film. Release studies showed that the amount of release could be easily controlled by changing the environmental conditions such as pH and ionic strength. Sustained release of loaded molecules was observed up to 8 h. The fabricated films were found to be biocompatible with epithelial cells during in-vitro cell culture studies. PEM film reported here not only has the potential to be used as self-responding thin film platform for transdermal drug delivery, but also has the potential for further development in antimicrobial or anti-inflammatory coatings on implants and drug-releasing coatings for stents.
机译：通过将聚烯丙胺盐酸盐（PAH）和聚（甲基丙烯酸）（PMA）进行逐层组装（LbL），设计了由弱聚电解质组成的聚电解质多层（PEM）薄膜，用于多种药物递送应用。环境刺激（例如pH和离子强度）在将薄膜形态从无孔的光滑结构转变为多孔结构方面表现出显着影响，并有利于负载分子的触发释放。通过调节膜的多孔聚合物网络，成功地将牛血清白蛋白（BSA）和盐酸环丙沙​​星（CH）加载到该膜中。释放研究表明，通过改变环境条件（例如pH值和离子强度）可以轻松控制释放量。观察到负载分子持续释放长达8小时。在体外细胞培养研究中，发现制成的膜与上皮细胞生物相容。此处报道的PEM膜不仅具有用作透皮药物输送的自响应薄膜平台的潜力，而且还具有进一步开发植入物上的抗菌或消炎涂层以及支架的释药涂层的潜力。

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