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首页> 外文期刊>Materials science & engineering >Development of porous Ti6Al4V/chitosan sponge composite scaffold for orthopedic applications
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Development of porous Ti6Al4V/chitosan sponge composite scaffold for orthopedic applications

机译：骨科用多孔Ti6Al4V /壳聚糖海绵复合支架的开发

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摘要

A novel composite scaffold consisting of porous Ti6Al4V part filled with chitosan sponge was fabricated using a combination of electron beam melting and freeze-drying. The mechanical properties of porous Ti6Al4V part were examined via compressive test The ultimate compressive strength was 85.35 ± 8.68 MPa and the compressive modulus was 2.26 ± 0.42 GPa. The microstructure of composite scaffold was characterized using scanning electron microscopy. The chitosan sponge filled in Ti6Al4V part exhibited highly porous and well-interconnected micro-pore architecture. The osteoblastic cells were seeded on scaffolds to test their seeding efficiency and biocompatibiiity. Significantly higher cell seeding efficiency was found on composite scaffold. The biological response of osteoblasts on composite scaffolds was superior in terms of improved cell attachment, higher proliferation, and well-spread morphology in relation to porous Ti6Al4V part These results suggest that the Ti6Al4V/chitosan composite scaffold is potentially useful as a biomedical scaffold for orthopedic applications.
机译：结合电子束熔化和冷冻干燥，制备了一种新型的复合支架，该支架由填充有壳聚糖海绵的多孔Ti6Al4V部分组成。通过压缩试验检查了多孔Ti6Al4V零件的力学性能。极限抗压强度为85.35±8.68 MPa，压缩模量为2.26±0.42 GPa。复合支架的微观结构用扫描电子显微镜表征。填充在Ti6Al4V部分中的壳聚糖海绵表现出高度多孔和良好互连的微孔结构。将成骨细胞接种在支架上以测试其接种效率和生物相容性。在复合支架上发现明显更高的细胞接种效率。与多孔Ti6Al4V部件相比，成骨细胞对复合支架的生物学反应在改善细胞附着，提高增殖和形态分布方面表现出优异的结果。这些结果表明，Ti6Al4V /壳聚糖复合支架可用作骨科的生物医学支架应用程序。

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  • 来源
    《Materials science & engineering》 |2016年第1期|1177-1181|共5页
  • 作者

    Miao Guo; Xiang Li;

  • 作者单位

    College of Life Information Science & Instrument Engineering, Hangzhou Dianzi University, Hangzhou 310018, China;

    School of Mechanical Engineering, Shanghai Jiao Tong University, State Key Laboratory of Mechanical System and Vibration, Shanghai 200240, China, 817 Mechanical Building A, 800 Dongchuan Road, Shanghai, China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Composite scaffold; Mechanical properties; Biocompatibiiity; Cell seeding efficiency;

    机译：复合脚手架;机械性能生物相容性细胞接种效率;

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