...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials science & engineering >Full factorial design optimization of anti-inflammatory drug release by PCL-PEG-PCL microspheres
【24h】

Full factorial design optimization of anti-inflammatory drug release by PCL-PEG-PCL microspheres

机译：PCL-PEG-PCL微球抗炎药释放的全因子设计优化

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

A biodegradable triblock poly(ε-caprolactone)-poly(ethylene glycol)-poly(ε-caprolactone) copolymer was successfully synthesized by ring-opening polymerization of ε-caprolactone, and was characterized by intrinsic viscosimetry, ~1H nuclear magnetic resonance, infrared spectroscopy and X-ray diffraction. Copolymer microparticles loaded with ibuprofen were prepared by an oil-in-water (o/w) emulsion solvent evaporation process. They were carefully weighted and characterized through their zeta potential. In this work, 4 selected process parameters (shaking speed X_1, time of contact X_2, poly(vinyl alcohol) concentration X_3, and ibuprofen concentration X_4) were adjusted at 2 different values. For each of the 16 experimental conditions, repeated twice, the drug encapsulation efficiency of the microspheres was determined, according to the following definition: EE (X_1, X_2, X_3, X_4) = mass of encapsulated ibuprofen / total weight of ibuprofen. A "full factorial design method" was applied to analyze the results statistically according to a polynomial fit and to determine the optimal conditions for the microencapsulation of the ibuprofen through an accurate statistical protocol. The microparticles obtained exhibit a spherical shape as shown by electron microscopy.
机译：通过ε-己内酯的开环聚合反应成功合成了可生物降解的三嵌段聚（ε-己内酯）-聚（乙二醇）-聚（ε-己内酯）共聚物，并通过固有粘度，〜1H核磁共振，红外光谱进行了表征。光谱学和X射线衍射。负载布洛芬的共聚物微粒是通过水包油（o / w）乳液溶剂蒸发工艺制备的。仔细评估了它们的重量，并通过zeta潜力进行了表征。在这项工作中，将四个选定的工艺参数（振动速度X_1，接触时间X_2，聚乙烯醇浓度X_3和布洛芬浓度X_4）调整为2个不同的值。对于16个实验条件中的每一个，重复两次，根据以下定义确定微球的药物包封效率：EE（X_1，X_2，X_3，X_4）=包封的布洛芬的质量/布洛芬的总重量。应用“全因子设计方法”根据多项式拟合对结果进行统计分析，并通过精确的统计方案确定布洛芬微囊化的最佳条件。所获得的微粒显示出如电子显微镜所示的球形。

著录项

  • 来源
    《Materials science & engineering》 |2016年第1期|412-419|共8页
  • 作者

    LHachemi Azouz; Farid Dahmoune; Farouk Rezgui; Christian GSell;

  • 作者单位

    Laboratoire des Materiaux Organiques (LMO), Faculte des Sciences Exactes, Department de Chimie, Universite de Bejaia, 06000 Bejaia Algerie;

    Laboratoire de Biomathematiques, Biophysique, Biochime et Scientometrie (L3BS-Bejaia), Faculte des Sciences de la Nature et de la Vie et des Sciences de la Terre, Universite de Bouira 10000 Bouira, Algerie;

    Laboratoire des Materiaux Organiques (LMO), Faculte de Technologie, Departement de Genie des Procedes, Universite de Bejaia, 06000 Bejaia, Algerie;

    Universite de Lorraine (France), Pole scientifique M4, Institut Jean Lamour (UMR CNRS-UL 7198), Departement SI2M, 54000 Nancy, France;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Poly(ε-caprolactone); Poly(ethylene glycol); Ibuprofen; Biodegradable polymers; Microspheres; Microencapsulation;

    机译：聚（ε-己内酯）;聚乙二醇）;布洛芬;可生物降解的聚合物;微球;微囊化;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号