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首页> 外文期刊>Materials science & engineering >Nanostructured material formulated acrylic bone cements with enhanced drug release
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Nanostructured material formulated acrylic bone cements with enhanced drug release

机译：纳米结构材料配制的丙烯酸骨水泥具有增强的药物释放能力

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摘要

To improve antibiotic properties, poly(methyl methacrylate) (PMMA)-based bone cements are formulated with antibiotic and nanostructured materials, such as hydroxyapatite (HAP) nanorods, carbon nanotubes (CNT) and mesoporous silica nanoparticles (MSN) as drug carriers. For nonporous HAP nanorods, the release of gentamicin (GTMC) is not obviously improved when the content of HAP is below 10%; while the high content of HAP shows detrimental to mechanical properties although the release of GTMC can be substantially increased. As a comparison, low content of hollow nanostructured CNT and MSN can enhance drug delivery efficiency. The presence of 5.3% of CNT in formulation can facilitate the release of more than 75% of GTMC in 80 days, however, its mechanical strength is seriously impaired. Among nanostructured drug carriers, antibiotic/MSN formulation can effectively improve drug delivery and exhibit well preserved mechanical properties. The hollow nanostructured materials are believed to build up nano-networks for antibiotic to diffuse from the bone cement matrix to surface and achieve sustained drug release. Based on MSN drug carrier in formulated bone cement, a binary delivery system is also investigated to release GTMC together with other antibiotics.
机译：为了改善抗生素性能，将聚甲基丙烯酸甲酯（PMMA）基骨水泥与抗生素和纳米结构材料（例如羟基磷灰石（HAP）纳米棒，碳纳米管（CNT）和中孔二氧化硅纳米颗粒（MSN））作为药物载体一起配制。对于无孔的HAP纳米棒，当HAP含量低于10％时，庆大霉素（GTMC）的释放不会明显改善。尽管高含量的HAP会损害机械性能，但GTMC的释放会大大增加。相比之下，中空纳米结构的CNT和MSN的含量低可以提高药物递送效率。配方中存在5.3％的CNT可以促进80天内释放出超过75％的GTMC，但是，其机械强度会受到严重损害。在纳米结构的药物载体中，抗生素/ MSN制剂可以有效地改善药物的输送并保持良好的机械性能。中空的纳米结构材料被认为可以建立纳米网络，使抗生素从骨水泥基质扩散到表面并实现持续的药物释放。基于配制骨水泥中的MSN药物载体，还研究了一种二元递送系统以与其他抗生素一起释放GTMC。

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  • 来源
    《Materials science & engineering》 |2016年第1期|233-241|共9页
  • 作者

    Shou-Cang Shen; Wai Kiong Ng; Yuan-Cai Dong; Junwei Ng; Reginald Beng Hee Tan;

  • 作者单位

    Institute of Chemical and Engineering Sciences, A~*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore;

    Institute of Chemical and Engineering Sciences, A~*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore;

    Institute of Chemical and Engineering Sciences, A~*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore;

    Institute of Chemical and Engineering Sciences, A~*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore;

    Institute of Chemical and Engineering Sciences, A~*STAR (Agency for Science, Technology and Research), 1 Pesek Road, Jurong Island, Singapore 627833, Singapore,Department of Chemical and Biomolecular Engineering, The National University of Singapore, 4 Engineering Drive 4, Singapore 117576, Singapore;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Bone cements; Antibiotic; Nanoparticles; Drug delivery; Diffusion network;

    机译：骨水泥;抗生素;纳米颗粒;药物输送;扩散网络;

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