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首页> 外文期刊>Materials science & engineering >Modified Au nanoparticles-imprinted sol-gel, multiwall carbon nanotubes pencil graphite electrode used as a sensor for ranitidine determination
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Modified Au nanoparticles-imprinted sol-gel, multiwall carbon nanotubes pencil graphite electrode used as a sensor for ranitidine determination

机译：修饰的金纳米颗粒压印溶胶-凝胶，多壁碳纳米管，铅笔石墨电极用作雷尼替丁测定的传感器

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摘要

A new, simple, and disposable molecularly imprinted electrochemical sensor for the determination of ranitidine was developed on pencil graphite electrode (PGE) via cyclic voltammetry (CV). The PGEs were coated with MWCNTs containing the carboxylic functional group (f-MWCNTs), imprinted with sol-gel and Au nanoparticle (AuNPs) layers (AuNP/MIP-sol-gel/f-MWCNT/PGE), respectively, to enhance the electrode's electrical transmission and sensitivity. The thin film of molecularly imprinted sol-gel polymers with specific binding sites for ranitidine was cast on modified PGE by electrochemical deposition. The AuNP/MIP-sol-gel/f-MWCNT/PGE thus developed was characterized by electrochemical impedance spectroscopy (EIS) and CV. The interaction between the imprinted sensor and the target molecule was also observed on the electrode by measuring the current response of 5.0 mM K_3[Fe(CN)_6] solution as an electrochemical probe. The pick currents of ranitidine increased linearly with concentration in the ranges of 0.05 to 2.0 uM, with a detection limit of (S/N = 3) 0.02 μM. Finally, the modified electrode was successfully employed to determine ranitidine in human urine samples.
机译：通过循环伏安法（CV）在铅笔石墨电极（PGE）上开发了一种用于测定雷尼替丁的新型，简单且一次性的分子印迹电化学传感器。将PGE涂有含有羧基官能团的MWCNT（f-MWCNT），分别印有溶胶-凝胶和金纳米颗粒（AuNPs）层（AuNP / MIP-sol-gel / f-MWCNT / PGE），以增强电极的电传输和灵敏度。通过电化学沉积将具有雷尼替丁特异性结合位点的分子印迹溶胶-凝胶聚合物薄膜浇铸在改性PGE上。由此开发的AuNP / MIP-溶胶-凝胶/ f-MWCNT / PGE用电化学阻抗谱（EIS）和CV表征。通过测量5.0 mM K_3 [Fe（CN）_6]溶液作为电化学探针的电流响应，还可以在电极上观察到印迹传感器与目标分子之间的相互作用。雷尼替丁的拾取电流随浓度在0.05到2.0 uM之间线性增加，检测极限为（S / N = 3）0.02μM。最后，修饰的电极成功地用于测定人尿液样品中的雷尼替丁。

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