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首页> 外文期刊>Materials science & engineering >Starch and chitosan oligosaccharides as interpenetrating phases in poly(N-isopropylacrylamide) injectable gels
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Starch and chitosan oligosaccharides as interpenetrating phases in poly(N-isopropylacrylamide) injectable gels

机译:淀粉和壳聚糖低聚糖作为聚(N-异丙基丙烯酰胺)注射凝胶的互穿相

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摘要

Thermosensitive interpenetrating gels were prepared by physically blending poly(N-isopropylacrylamide) (PNIPA) as the matrix and the following polysaccharides as interpenetrating phases: chitosan oligosaccharides (identified as QNAD and QNED) and soluble starch (STARCH). The molecular weight of the dispersed phase, the free water/bound water ratio and the thermosensitivity (transition temperature: LCST) of the gels were determined. It was found that these gels are pseudoplastic and that their viscosity depends on the molecular weight of the dispersed phase. LCST transition occurred around 35-37℃. The morphology of the porosity of the freeze-dried samples was studied by Scanning Electron Microscopy (SEM). An in vitro test of cell hemolysis on blood agar showed that these gels are noncytotoxic. According to the results obtained, these interpenetrating gels show characteristics of an injectable material, and have a transition LCST at body temperature, which reinforces their potential to be used in the surgical field and as scaffolds for tissue engineering.
机译:通过物理共混作为基质的聚(N-异丙基丙烯酰胺)(PNIPA)和以下多糖作为互穿相来制备热敏互穿凝胶:壳聚糖寡糖(标识为QNAD和QNED)和可溶性淀粉(STARCH)。测定了分散相的分子量,自由水/结合水的比率以及凝胶的热敏性(转变温度:LCST)。已经发现这些凝胶是假塑性的,并且它们的粘度取决于分散相的分子量。 LCST转变发生在35-37℃左右。通过扫描电子显微镜(SEM)研究了冻干样品的孔隙形态。在血琼脂上进行细胞溶血的体外测试表明,这些凝胶无细胞毒性。根据获得的结果,这些互穿凝胶显示出可注射材料的特性,并在体温下具有过渡LCST,这增强了它们在外科手术领域和组织工程支架中使用的潜力。

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