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首页> 外文期刊>Materials science & engineering >pH- and thermo-responsive microcontainers as potential drug delivery systems: Morphological characteristic, release and cytotoxicity studies
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pH- and thermo-responsive microcontainers as potential drug delivery systems: Morphological characteristic, release and cytotoxicity studies

机译：pH响应和热响应微容器作为潜在的药物输送系统：形态特征，释放和细胞毒性研究

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摘要

Polymeric pH- and thermo-sensitive microcontainers (MCs) were developed as a potential drug delivery system for cancer therapy. It is well known that cancer cells exhibit notable characteristics such as acidic pH due to glycolytic cycle and higher temperature due to their higher proliferation rate. Based on these characteristics, we constructed a dual pH- and thermo-sensitive material for specific drug release on the pathological tissue. The MC's fabrication is based on a two-step procedure, in which, the first step involves the core synthesis and the second one is related to the shell formation. The core consists of poly(methyl methacrylate (PMMA), while the shell consists of PMMA, poly(isopropylacrylamide), poly(acrylic acid) and poly(divinylbenzene). Three different types of MCs were synthesized based on the seed polymerization method. The synthesized MCs were characterized structurally by Fourier transform infrared and morphologically by scanning electron microscopy. Dynamic light scattering was also used to study their behavior in aqueous solution under different pH and temperature conditions. For the loading and release study, the anthracydine drug daunorubicin (DNR) was used as a model drug, and its release properties were evaluated under different pH and thermo-conditions. Cytotoxicity studies were also carried out against MCF-7 breast cancer and 3T3 mouse embryonic fibroblast cells. According to our results, the synthesized microcontainers present desired pH and thermo behavior and can be applied in drug delivery systems. It is worth mentioning that the synthesized microcontainers which incorporated the drug DNR exhibit higher toxicity than the free drug.
机译：聚合的pH敏感和热敏感的微容器（MC）被开发为用于癌症治疗的潜在药物输送系统。众所周知，癌细胞由于糖酵解循环而表现出显着的特性，例如酸性pH，并且由于其较高的增殖速率而表现出较高的温度。基于这些特征，我们构建了一种pH和热敏双重材料，用于在病理组织上释放特定的药物。 MC的制造基于两步过程，其中第一步涉及核的合成，第二步涉及壳的形成。核由聚甲基丙烯酸甲酯（PMMA）组成，壳由聚甲基丙烯酸甲酯（PMMA），聚（异丙基丙烯酰胺），聚（丙烯酸）和聚（二乙烯基苯）组成，通过种子聚合法合成了三种不同类型的MC。通过傅里叶变换红外光谱对其结构进行表征，并通过扫描电子显微镜对其形态进行表征，并通过动态光散射研究其在水溶液中在不同pH和温度条件下的行为；蒽环类药物柔红霉素（DNR）的负载和释放研究作为模型药物，在不同的pH和温度条件下评估了其释放特性，并对MCF-7乳腺癌和3T3小鼠胚胎成纤维细胞进行了细胞毒性研究，根据我们的结果，合成的微容器具有理想的应用价值。 pH和热行为，可用于药物输送系统，值得一提的是合成的麦克风掺入了药物DNR的rotaintainer的毒性要高于游离药物。

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  • 来源
    《Materials science & engineering》 |2014年第4期|271-277|共7页
  • 作者

    Eleni K. Efthimiadou; Christos Tapeinos; Leto-Aikaterini Tziveleka; Nikos Boukos; George Kordas;

  • 作者单位

    Sol-Gel Laboratory, Institute for Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, NCSR 'Demokritos', 15 341 Aghia Paraskevi Attikis, Greece;

    Sol-Gel Laboratory, Institute for Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, NCSR 'Demokritos', 15 341 Aghia Paraskevi Attikis, Greece,Materials Science Department, School of Natural Sciences, University of Patras, 26 500 Patras, Greece;

    Sol-Gel Laboratory, Institute for Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, NCSR 'Demokritos', 15 341 Aghia Paraskevi Attikis, Greece;

    Sol-Gel Laboratory, Institute for Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, NCSR 'Demokritos', 15 341 Aghia Paraskevi Attikis, Greece;

    Sol-Gel Laboratory, Institute for Advanced Materials, Physicochemical Processes, Nanotechnology and Microsystems, NCSR 'Demokritos', 15 341 Aghia Paraskevi Attikis, Greece;

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  • 正文语种 eng
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  • 关键词

    Drug delivery systems; Dual responsive; Hollow microcontainers; pH sensitivity; Thermo-sensitivity;

    机译：药物输送系统;双重响应;中空微容器;pH敏感性;热敏性;

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