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首页> 外文期刊>Materials science & engineering >Tantalum coating on TiO_2 nanotubes induces superior rate of matrix mineralization and osteofunctionality in human osteoblasts
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Tantalum coating on TiO_2 nanotubes induces superior rate of matrix mineralization and osteofunctionality in human osteoblasts

机译：TiO_2纳米管上的钽涂层可诱导人类成骨细胞中较高的基质矿化速率和骨功能

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摘要

Nanostructured surface geometries have been the focus of a multitude of recent biomaterial research, and exciting findings have been published. However, only a few publications have directly compared nanostructures of various surface chemistries. The work herein directly compares the response of human osteoblast cells to surfaces of identical nanotube geometries with two well-known orthopedic biomaterials: titanium oxide (TiO_2) and tantalum (Ta). The results reveal that the Ta surface chemistry on the nanotube architecture enhances alkaline phos-phatase activity, and promotes a ～30% faster rate of matrix mineralization and bone-nodule formation when compared to results on bare TiO_2 nanotubes. This study implies that unique combinations of surface chemistry and nanostructure may influence cell behavior due to distinctive physico-chemical properties. These findings are of paramount importance to the orthopedics field for understanding cell behavior in response to subtle alterations in nanostructure and surface chemistry, and will enable further insight into the complex manipulation of biomaterial surfaces. With increased focus in the field of orthopedic materials research on nanostructured surfaces, this study emphasizes the need for careful and systematic review of variations in surface chemistry in concurrence with nanotopographical changes.
机译：纳米结构的表面几何形状已成为许多近期生物材料研究的焦点，并且令人兴奋的发现已经发表。然而，只有少数出版物直接比较了各种表面化学的纳米结构。本文的工作直接用两种众所周知的骨科生物材料比较了人类成骨细胞对相同纳米管几何形状表面的反应：氧化钛（TiO_2）和钽（Ta）。结果表明，与裸露的TiO_2纳米管相比，纳米管结构上的Ta表面化学成分增强了碱性磷酸酶的活性，并促进了约30％的基质矿化和骨结节形成。这项研究表明，由于独特的物理化学性质，表面化学和纳米结构的独特组合可能会影响细胞行为。这些发现对于整形外科领域至关重要，对于了解细胞行为以响应纳米结构和表面化学的细微变化，并将使我们对生物材料表面的复杂操作有更深入的了解。随着在整形外科材料领域对纳米结构表面研究的日益关注，这项研究强调需要对与纳米形貌变化同时发生的表面化学变化进行仔细而系统的审查。

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  • 来源
    《Materials science & engineering》 |2014年第4期|332-341|共10页
  • 作者

    Christine J. Frandsen; Karla S. Brammer; Kunbae Noh; Gary Johnston; Sungho Jin;

  • 作者单位

    Materials Science & Engineering. University of California at San Diego, La Jolla, CA 92093, United States;

    Materials Science & Engineering. University of California at San Diego, La Jolla, CA 92093, United States;

    Corporate Research Institute, Cheil Industries, Inc., Gocheon-Dong, Uiwang-Si, Gyeonggi-Do, 437-711, Republic of Korea;

    Materials Science & Engineering. University of California at San Diego, La Jolla, CA 92093, United States;

    Materials Science & Engineering. University of California at San Diego, La Jolla, CA 92093, United States,Mechanical & Aerospace Engineering, University of California at San Diego, 9500 Gilman Dr., La Jolla, CA 92093-0411, United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    TiO_2 nanotubes; Tantalum; Osteoblast; Cell adhesion; Alkaline phosphatase activity; Matrix mineralization;

    机译：TiO_2纳米管;钽成骨细胞;细胞粘附;碱性磷酸酶活性;基质矿化;

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