...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials science & engineering >Production and characterization of cornstarch/cellulose acetate/silver sulfadiazine extrudate matrices
【24h】

Production and characterization of cornstarch/cellulose acetate/silver sulfadiazine extrudate matrices

机译：玉米淀粉/醋酸纤维素/磺胺嘧啶银挤出物基质的生产与表征

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The production and evaluation of cornstarch/cellulose acetate/silver sulfadiazine extrudate matrices are reported herein. The matrices were melt extruded under nine different conditions, altering the temperature and the screw speed values. The surface morphology of the matrices was examined by scanning electron microscopy. The micrographs revealed the presence of non-melted silver sulfadiazine microparticles in the matrices extruded at lower temperature and screw speed values. The thermal properties were evaluated and the results for both the biopolymer and the drug indicated no thermal degradation during the melt extrusion process. The differential scanning analysis of the extrudate matrices showed a shift to lower temperatures for the silver sulfadiazine melting point compared with the non-extruded drug. The starch/cellulose acetate matrices containing silver sulfadiazine demonstrated significant inhibition of the growth of Pseudomonas aeruginosa and Staphylococcus aureus. In vivo inflammatory response tests showed that the extrudate matrices, with or without silver sulfadiazine, did not trigger chronic inflammatory processes.
机译：本文报道了玉米淀粉/乙酸纤维素/磺胺嘧啶银挤出物基质的生产和评价。在九种不同条件下将基体熔融挤出，从而改变温度和螺杆速度值。基质的表面形态通过扫描电子显微镜检查。显微照片显示在较低温度和螺杆速度值下挤出的基质中存在未熔融的磺胺嘧啶银微粒。评估了热性能，生物聚合物和药物的结果均表明在熔融挤出过程中没有热降解。挤出物基质的差示扫描分析显示，与未挤出药物相比，磺胺嘧啶银的熔点转移到了更低的温度。含有磺胺嘧啶银的淀粉/醋酸纤维素基质对铜绿假单胞菌和金黄色葡萄球菌的生长具有明显的抑制作用。体内炎症反应测试表明，有或没有磺胺嘧啶银的挤出物基质均未触发慢性炎症过程。

著录项

  • 来源
    《Materials science & engineering》 |2014年第11期|225-233|共9页
  • 作者

    Karine Modolon Zepon; Fabricia Petronilho; Valdir Soldi; Gean Vitor Salmoria; Luiz Alberto Kanis;

  • 作者单位

    CIMJECT, Departamento de Engenharia Mecanica, Universidade Federal de Santa Catarina 88040-900 Florianopolis, SC, Brazil,TECFARMA, Universidade do Sul de Santa Catarina, 88704-900 Tubarao, SC, Brazil;

    FICEXP, Universidade do Sul de Santa Catarina, 88704-900 Tubarao, SC, Brazil;

    POLIMAT, Universidade Federal de Santa Catarina, 88040-900 Florianopolis, SC, Brazil;

    CIMJECT, Departamento de Engenharia Mecanica, Universidade Federal de Santa Catarina 88040-900 Florianopolis, SC, Brazil;

    TECFARMA, Universidade do Sul de Santa Catarina, 88704-900 Tubarao, SC, Brazil;

  • 收录信息
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cornstarch/cellulose acetate; Silver sulfadiazine; Extrudate matrices;

    机译：玉米淀粉/醋酸纤维素;磺胺嘧啶银;挤出基质;

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号