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One step poly(rutin) particle preparation as biocolloid and its characterization

机译：一步法制备聚芦丁颗粒作为生物胶体及其表征

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摘要

Poly(rutin) p(RT) particles were prepared for the first time via a simple microemulsion polymerization/crosslinking method using l-α lecithin as surfactant, cyclohexane as organic phase and glycerol diglycidyl ether (GDE) as a crosslinking agent Highly negatively charged p(RT) particles, -48.2 mV, were obtained due to phenolic groups on the particles. It was also confirmed that p(RT) particles are thermally more stable than RT and degradable in PBS at pH 7.4., e.g., 11 wt.% can degrade in 1 day and little further degradation was observed over 9 days. The prepared p(RT) particles showed insignificant antibacterial characteristics against common bacteria such as Escherichia coli ATCC8739, Staphylococcus aureus ATCC6538, and Bacillus subtilis ATCC6633 whereas the RT molecules showed significantly better antibacterial characteristics even at low concentrations. Moreover, p(RT) particles were demonstrated for use as drug delivery devices by loading rosmarinic acid (RA) as model drug and showed release capability for up to 6 days by releasing 85% of the loaded RA. Intriguingly, p(RT) particles illustrated enhanced fluorescent properties providing great potential for fluorescent active antioxidant and antibacterial materials in biomedical use.
机译：首次通过简单的微乳液聚合/交联方法，使用l-α卵磷脂作为表面活性剂，环己烷作为有机相和甘油二缩水甘油醚（GDE）作为交联剂，首次制备了聚（芦丁）p（RT）颗粒。由于颗粒上的酚基，获得了（RT）颗粒-48.2 mV。还证实p（RT）颗粒比RT更热稳定并且在pH 7.4的PBS中可降解，例如11重量％可在1天内降解，并且在9天内几乎观察不到进一步降解。制备的p（RT）颗粒对普通细菌（如大肠杆菌ATCC8739，金黄色葡萄球菌ATCC6538和枯草芽孢杆菌ATCC6633）的抗菌特性不明显，而RT分子即使在低浓度下也显示出明显更好的抗菌特性。此外，通过将迷迭香酸（RA）加载为模型药物，p（RT）颗粒被证明可以用作药物传递装置，并且通过释放85％的RA可以显示长达6天的释放能力。有趣的是，p（RT）颗粒显示出增强的荧光特性，为生物医学用途中的荧光活性抗氧化剂和抗菌材料提供了巨大潜力。

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