Effects of fluid flow shear rate and surface roughness on the calcification of polymeric heart valve leaflet

Parnian Boloori_Zadeh; Scott C. Corbett; Hamid Nayeb-Hashemi

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Effects of fluid flow shear rate and surface roughness on the calcification of polymeric heart valve leaflet

机译：流体剪切速率和表面粗糙度对聚合物心脏瓣膜钙化的影响

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摘要

Surface defects, blood flow shear rates and mechanical stresses are contributing factors in the calcification process of polymeric devices exposed to the blood flow. A number of experiments were performed to evaluate the effect of surface defects such as roughness and cracks and flow shear rate on the calcification process of a polyurethane material used in the design of prosthetic heart valves. Results showed that polyurethane surface gets calcified and the calcification is more pronounced at the lower shear rates. Roughness and cracks both increase the calcification levels. The results also suggest very little diffusion of calcium to the subsurface indicating that calcification of a polyurethane material, is a surface phenomenon. Based on a simple peeling test, the bond strength between the calcified layer and polyurethane was found to be extremely weak, suggesting that the bonding is in the form of Van-der-Waals. A limited set of experiments with polycarbonate showed that polycarbonate is less prone to calcification compared to polyurethane (p values less than 0.05), indicating its potential application in medical devices exposed to blood flow.

机译：表面缺陷，血流剪切速率和机械应力是暴露于血流的聚合物装置钙化过程的影响因素。进行了许多实验，以评估表面缺陷（如粗糙度和裂缝以及流动剪切速率）对用于人工心脏瓣膜设计的聚氨酯材料钙化过程的影响。结果表明，在较低的剪切速率下，聚氨酯表面被钙化，钙化现象更加明显。粗糙度和裂纹都增加了钙化水平。结果还表明，钙几乎不扩散到地下，表明聚氨酯材料的钙化是表面现象。根据简单的剥离试验，发现钙化层与聚氨酯之间的结合强度非常弱，表明该结合是以范德华尔形式存在的。一组有限的聚碳酸酯实验表明，与聚氨酯相比，聚碳酸酯不易钙化（p值小于0.05），表明其在暴露于血流的医疗设备中的潜在应用。

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《Materials science & engineering》 |2013年第5期|2770-2775|共6页
作者
Parnian Boloori_Zadeh; Scott C. Corbett; Hamid Nayeb-Hashemi;
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作者单位

Department of Mechanical and Industrial Engineering, Northeastern University, 334 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115-5000, United States;

Research and Development, Abiomed Inc., 22 Cherry Hill Drive, Danvers, MA 01923, United States;

Department of Mechanical and Industrial Engineering, Northeastern University, 334 Snell Engineering Center, 360 Huntington Avenue, Boston, MA 02115-5000, United States;

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正文语种 eng
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关键词
Polyurethane; Calcification; Angioflex; Shear rate; Heart valve;

机译：聚氨酯钙化;Angioflex;剪切率;心脏瓣膜;

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1. Effects of fluid flow shear rate and surface roughness on the calcification of polymeric heart valve leaflet [J] . Boloori-zadeh P., Corbett S.C., Nayeb-Hashemi H. Materials science & engineering, C. Materials for Biogical applications . 2013,第5期

机译：流体剪切速率和表面粗糙度对聚合物心脏瓣膜钙化的影响
2. Direction and Magnitude of Blood Flow Shear Stresses on the Leaflets of Aortic Valves: Is There a Link With Valve Calcification? [J] . Liang Ge, Fotis Sotiropoulos Journal of biomechanical engineering. . 2010,第1期

机译：主动脉瓣小叶上的血流切应力的方向和大小：瓣膜钙化有联系吗？
3. The anti-calcification potential of a silsesquioxane nanocomposite polymer under in vitro conditions: potential material for synthetic leaflet heart valve. [J] . Ghanbari H, Kidane AG, Burriesci G, Acta biomaterialia . 2010,第11期

机译：倍半硅氧烷纳米复合聚合物在体外条件下的抗钙化潜力：合成小叶心脏瓣膜的潜在材料。
4. Prevention of Calcification and Lipid Lowering Effects of a Long-Chain Alcohol Based Treatment of Porcine Heart Valve Leaflets [C] . Alan K. Adams, C.P.Pathak, Brian K. McIlroy, Annual meeting of the Society For Biomaterials . 2002

机译：预防基于长链醇的猪心脏瓣膜小叶钙化和降血脂作用
5. Quantification Of Leaflet flutter in Bioprosthetic Heart Valves Using Fluid-Structure Interaction Analysis [D] . Wiese, Nelson Michael. 2018

机译：使用流体 - 结构相互作用分析量化生物假体心脏瓣膜叶片的量化
6. Experimental measurement of dynamic fluid shear stress on the ventricular surface of the aortic valve leaflet [O] . Choon Hwai Yap, Neelakantan Saikrishnan, Ajit P. Yoganathan -1

机译：主动脉瓣叶片心室表面动态流体剪切应力的实验测量
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Effects of fluid flow shear rate and surface roughness on the calcification of polymeric heart valve leaflet

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