...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Materials science & engineering >Nanostructured medical device coatings based on self-assembled poly(lactic-co-glycolic acid) nanoparticles
【24h】

Nanostructured medical device coatings based on self-assembled poly(lactic-co-glycolic acid) nanoparticles

机译：基于自组装聚乳酸-乙醇酸纳米颗粒的纳米结构医疗器械涂料

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Here we present a new method for providing nanostructured drug-loaded polymer films which enable control of film surface morphology and delivery of therapeutic agents. Silicon wafers were employed as models for implanted biomaterials and poly(lactic-co-glycolic acid) (PLGA) nanoparticles were assembled onto the silicon surface by electrostatic interaction. Monolayers of the PLGA particles were deposited onto the silicon surface upon incubation in an aqueous particle suspension. Particle density and surface coverage of the silicon wafers were varied by altering particle concentration, incubation time in nanoparticle suspension and ionic strength of the suspension. Dye loaded nanoparticles were prepared and assembled to silicon surface to form nanopartide films. Fluorescence intensity measurements showed diffusion-controlled release of the dye over two weeks and atomic force microscopy (AFM) analysis revealed that these particles remained attached to the surface during the incubation time. This work suggests that coating implants with PLGA nanopartides is a versatile technique which allows drug release from the implant surface and modulation of surface morphology.
机译：在这里，我们介绍了一种提供纳米结构的载有药物的聚合物薄膜的新方法，该薄膜能够控制薄膜表面的形态和治疗剂的输送。硅晶片被用作植入生物材料的模型，聚乳酸-乙醇酸共聚物（PLGA）纳米粒子通过静电相互作用组装到硅表面上。在水性颗粒悬浮液中孵育后，将PLGA颗粒的单层沉积在硅表面上。通过改变颗粒浓度，纳米颗粒悬浮液中的孵育时间和悬浮液的离子强度来改变硅晶片的颗粒密度和表面覆盖率。制备染料负载的纳米颗粒，并将其组装到硅表面以形成纳米粒子膜。荧光强度测量显示染料在两周内扩散受控地释放，原子力显微镜（AFM）分析表明这些颗粒在孵育时间内仍附着在表面。这项工作表明，用PLGA纳米粒子包被植入物是一种通用技术，它可以使药物从植入物表面释放出来并调节表面形态。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号