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首页> 外文期刊>Materials science & engineering >Synthesis and properties of regenerated cellulose-based hydrogels with high strength and transparency for potential use* as an ocular bandage
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Synthesis and properties of regenerated cellulose-based hydrogels with high strength and transparency for potential use* as an ocular bandage

机译:具有高强度和透明度的再生纤维素基水凝胶的合成和性能,可潜在地用作眼用绷带*

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摘要

Cellulose is a biologically derived material with excellent wound-healing properties. The high strength of cellulose fibers and the ability to synthesize gels with high optical transparency make these materials suitable for ocular applications. In this study, cellulose materials derived from wood pulp, cotton, and bacterial sources were dissolved in lithium chloride/N,N-dimethylacetamide to form regenerated cellulose hydrogels. Material properties of the resulting hydrogels, including water content, optical transparency, and tensile and tear strengths, were evaluated. Synthesis parameters, including activation time, dissolution time, relative humidity, and cellulose concentration, were found to impact the material properties of the resulting hydrogels. Overnight activation time improves the optical transparency of the hydrogels from 77% to 97% at 550 nm whereas controlling cellulose concentration improves their tear strength by as much as 200%. On the basis of the measured transmittance and strength values of the regenerated hydrogels prepared via the optimized synthesis parameters, Avicel PH 101, Sigma-Aldrich microcrystalline cellulose 435236, and bacterial cellulose types were prioritized for future biocompatibility testing and potential clinical investigation.
机译:纤维素是具有优异伤口愈合特性的生物来源材料。纤维素纤维的高强度和合成具有高光学透明性的凝胶的能力使这些材料适合眼用。在这项研究中,将木浆,棉花和细菌来源的纤维素材料溶解在氯化锂/ N,N-二甲基乙酰胺中,形成再生的纤维素水凝胶。评价了所得水凝胶的材料性能,包括水含量,光学透明性以及拉伸强度和撕裂强度。已发现包括活化时间,溶解时间,相对湿度和纤维素浓度在内的合成参数会影响所得水凝胶的材料性能。过夜活化时间可将水凝胶在550 nm处的光学透明度从77%提高到97%,而控制纤维素浓度可将其撕裂强度提高多达200%。根据通过优化的合成参数制备的再生水凝胶的测量透射率和强度值,优先考虑Avicel PH 101,Sigma-Aldrich微晶纤维素435236和细菌纤维素类型,以用于未来的生物相容性测试和潜在的临床研究。

著录项

  • 来源
    《Materials science & engineering》 |2013年第5期|3069-3076|共8页
  • 作者单位

    Research and Exploratory Development Department, The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, United States;

    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, 720 Rutland Avenue/Ross 720, Baltimore, MD 21205, United States;

    Research and Exploratory Development Department, The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, United States;

    Research and Exploratory Development Department, The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, United States;

    Research and Exploratory Development Department, The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, United States,Wilmer Eye Institute, Johns Hopkins Medical Institutions, 600 N, Wolfe Street, Baltimore, MD 21287, United States;

    Wilmer Eye Institute, Johns Hopkins Medical Institutions, 600 N, Wolfe Street, Baltimore, MD 21287, United States;

    Department of Biomedical Engineering, Johns Hopkins University, School of Medicine, 720 Rutland Avenue/Ross 720, Baltimore, MD 21205, United States;

    Research and Exploratory Development Department, The Johns Hopkins University Applied Physics Laboratory, 11100 Johns Hopkins Road, Laurel, MD 20723, United States;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Cellulose; Hydrogel; Transparency; Tear strength; Ocular bandage;

    机译:纤维素;水凝胶;透明度;撕裂强度;眼绷带;

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