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首页> 外文期刊>Materials science & engineering >Evaluation of bacterial nanocellulose-based uniform wound dressing for large area skin transplantation
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Evaluation of bacterial nanocellulose-based uniform wound dressing for large area skin transplantation

机译：基于细菌纳米纤维素的均匀伤口敷料在大面积皮肤移植中的评估

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摘要

Bacterial nanocellulose (BNC) was biosynthesized by Gluconacetobacter xylinus. The surface area, physico-chemical structure and morphology of the materials were characterized. Here provides a method for an efficient production of uniform BNC, which is beneficial for the fast characterization and evaluation of BNC. In vitro cytotoxicity of the materials was evaluated by the proliferation, the adhesion, the viability and the morphology of NIH/3T3 cells. Low cytotoxicity of the BNC was observed, and micrographs demonstrate a good proliferation and adhesion of NIH/3T3 cells on BNC Large area full-thickness skin defects were made on the back of CS7BL/6 mice in animal surgery. The wounds were transplanted with BNC films and the results compared to those in a control group. The rehabilitation of the wound surfaces and the pathological sections of mice were investigated and are discussed. Histological examinations demonstrated faster and better healing effect and lower inflammatory response in the BNC group than those in the control group. Preliminary results on wound dressings from BNC show a curative effect promoting the healing of epithelial tissue. BNC is a promising natural polymer with medical applications in wound dressings.
机译：木糖葡糖杆菌生物合成细菌纳米纤维素（BNC）。表征了材料的表面积，理化结构和形态。这里提供了一种有效生产均匀BNC的方法，这对BNC的快速表征和评估是有利的。通过NIH / 3T3细胞的增殖，粘附，生存力和形态来评估材料的体外细胞毒性。观察到BNC的细胞毒性较低，并且显微照片显示NIH / 3T3细胞在BNC上具有良好的增殖和粘附性。在动物手术中，CS7BL / 6小鼠的背部出现了大面积全厚度皮肤缺损。将伤口用BNC膜移植，并将结果与​​对照组比较。对小鼠伤口表面和病理切片的修复进行了研究并进行了讨论。组织学检查显示，BNC组比对照组更快，更好的愈合效果和更低的炎症反应。 BNC伤口敷料的初步结果显示出促进上皮组织愈合的疗效。 BNC是有前途的天然聚合物，在伤口敷料中具有医学应用。

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  • 来源
    《Materials science & engineering》 |2013年第5期|2995-3000|共6页
  • 作者

    Lina Fu; Ping Zhou; Shengmin Zhang; Guang Yang;

  • 作者单位

    Department of Biomedical Engineering, College of life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China,National Engineering Research Center for Nano-Medicine, Huazhong University of Science and Technology, Wuhan 430074, PR China;

    Institute of Organ Transplant of Tongji Hospital, Huazhong University of Science and Technology, Wuhan, PR China;

    Advanced Biomaterials and Tissue Engineering Center, Huazhong University of Science and Technology, Wuhan, PR China;

    Department of Biomedical Engineering, College of life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, PR China,National Engineering Research Center for Nano-Medicine, Huazhong University of Science and Technology, Wuhan 430074, PR China;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Bacterial nanocellulose; Wound dressing; Skin transplantation; Evaluation;

    机译：细菌纳米纤维素;伤口敷料;皮肤移植;评价;

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