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首页> 外文期刊>Materials science & engineering >Biofilm formation to inhibition: Role of zinc oxide-based nanoparticles
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Biofilm formation to inhibition: Role of zinc oxide-based nanoparticles

机译：生物膜形成抑制：氧化锌的纳米粒子的作用

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Zinc oxide nanoparticles have received much attention worldwide as they possess unique properties like varied morphology, large surface area to volume ratio, potent antibacterial activity, and biocompatibility. Biofilm contains homogenous or heterogeneous microorganisms that remain enclosed in a matrix of an extracellular polymeric substance on biotic or abiotic surfaces. Bacterial biofilm formed on medical devices such as central venous catheters, urinary catheters, prosthetic joints, cardiovascular implantable devices, dental implants, contact lenses, intrauterine contraceptive devices and breast implants cause persistent infections. Such biofilm-associated infections in medical implants cause serious problems for public health and affect the function of medical implants. So, there is an urgent need for the use of an antimicrobial agent that will inhibit biofilm, including such antibiotic-resistant bacterial strains as bacteria, to develop multiple drug-resistances resulting in failure of the antibiotic's action. The antimicrobial agent used should be ideal in terms of biocompatibility, antimicrobial activity, stability at different environmental conditions, with less sensitivity to the development of resistance towards micro-organisms, safe for in vivo and in vitro use, and remain non-hazardous to the environment, etc. The first objective of the review discusses the insights into the formation of biofilm on a medical device with the current strategies to inhibit. The second purpose is to review the recent progress in ZnO- based nanostructure including composites for antibacterial and anti-biofilm activities. This will offer a new opportunity for the application of Zinc oxide-based material in the prevention of biofilm on the medical devices.
机译：氧化锌纳米颗粒在全球上受到了很多关注，因为它们具有不同形态的独特性质，表面积大的表面积为体积比，有效的抗菌活性和生物相容性。生物膜含有均匀或异质的微生物，其在生物或非生物表面上保留在细胞外聚合物物质的基质中。在诸如中央静脉导管，泌尿导管，假性关节，心血管植入装置，牙科植入物，隐形眼镜，宫内避孕装置和乳房植入物等医疗装置上形成的细菌生物膜，患有持续的感染。医疗植入物中的这种生物膜相关的感染对公共卫生产生严重问题，影响医疗植入物的功能。因此，迫切需要使用将抑制生物膜的抗微生物剂，包括这种抗生素的细菌菌株作为细菌，以产生多种抗药性作用失效的药物抗药性。使用的抗微生物剂应在生物相容性，抗微生物活性，不同环境条件下的稳定性方面是理想的，对微生物的抗性的敏感性较小，体内和体外使用的安全性，并且对此持续不危险环境等审查的第一个目标讨论了在医疗器械中形成生物膜的洞察力，以目前的策略抑制。第二个目的是回顾基于ZnO的纳米结构的最近进展，包括用于抗菌和抗生物膜活性的复合材料。这将为应用氧化锌基材料在医疗装置上预防生物膜中的应用提供新的机会。

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